Active Recombinant Human Interleukin 6 (Interferon, Beta 2)
Cat.No. : | IL6-128H |
Product Overview : | Recombinant Human interleukin 6 (interferon, beta 2) protein sequence (containing the signal peptide sequence, and the mature human Interleukin 4 sequence) and was expressed in modifiedhuman 293 cells. |
- Specification
- Gene Information
- Related Products
Cat. No. : | IL6-128H |
Description : | IL-6 is a pleotropic cytokine that regulates the development, proliferation and maturation of a number of hematopoietic cells and is essential for the maturation of B cells into immunoglobulin-secreting cells. |
Source : | Human 293 cells. |
Amino Acid Sequence : | APVPPGEDSKDVAA PHRQPLTSSER IDKQIRYILDG ISALRKETCN KSNMCESSK EALAENNLN LPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVY LEYLQNRFE SSE EQARAV QMST KVLIQFL QKKAKN LDAITTPDPTT NASLLTKLQA QNQWLQDMT T HLI L RSFK EFLQSSLRALRQM. |
Molecular Mass : | IL-6 migrates as a broad band between 20 and 25 kDa in SDS-PAGE due to post-translation modifications, in particular glycosylation. This compares with the unmodified IL-6 that has a predicted molecular mass of 21.0kDa. |
PI : | IL-6 separates into a number of isoforms with a pI between 5.5 and 7.2 in 2D PAGE due to post-translational modifications, in particular glycosylation. This compares with the unmodified IL-6 that has a predicted pI of 6.22. |
% Carbohydrate : | Purified IL-6 consists of 0-20% carbohydrate by weight. |
Purity : | >95%, as determined by SDS-PAGE and visualized by silver stain. |
Formulation : | When reconstituted in 0.5 ml sterile phosphate-buffered saline, the solution will contain 1% human serum albumin (HSA) and 10% trehalose. |
Reconstitution : | It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. |
Storage : | Lyophilized products should be stored at 2 to 8°C. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended. |
Activity : | The ED50of IL-6 is typically 0.15 - 0.35 ng/ml as measured in a cell proliferation assay using a human growth factor-dependent TF-1 cell line. |
Gene Name : | IL6 interleukin 6 (interferon, beta 2) [ Homo sapiens ] |
Synonyms : | IL6; interleukin 6 (interferon, beta 2); BSF2; HGF; HSF; IFNB2; IL-6; B cell stimulatory factor-2; B-cell differentiation factor; CTL differentiation factor; OTTHUMP00000158544; hybridoma growth factor; interleukin 6; interleukin BSF-2; (interferon, beta 2); Hybridoma growth factor |
Gene ID : | 3569 |
mRNA Refseq : | NM_000600 |
Protein Refseq : | NP_000591 |
MIM : | 147620 |
UniProt ID : | P05231 |
Chromosome Location : | 7p21 |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Hematopoietic cell lineage; Graft-versus-host disease; Hypertrophic cardiomyopathy (HCM); Pathways in cancer; Prion diseases; Toll-like receptor signaling pathway |
Function : | interleukin-6 receptor activity; cytokine activity; growth factor activity |
Products Types
◆ Recombinant Protein | ||
IL6-2003M | Recombinant Mouse IL6 Protein | +Inquiry |
Il6-212M | Recombinant Active Mouse IL6 Protein, His-tagged(C-ter) | +Inquiry |
Il6-176I | Active Recombinant Rat Il6 Protein | +Inquiry |
IL6-184H | Active Recombinant Human IL6 Protein | +Inquiry |
IL6-052H | Recombinant Human IL6 Mutant (R44M) Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
IL6-5224HCL | Recombinant Human IL6 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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