| Description : |
This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
113.4 kDa |
| AA Sequence : |
MARALCPLQALWLLEWVLLLLGPCA APPAWALNLDPVQLTFYAGPNGSQF GFSLDFHKDSHGRVAIVVGAPRTLG PSQEETGGVFLCPWRAEGGQCPSLL FDLRDETRNVGSQTLQTFKARQGLG ASVVSWSDVIVACAPWQHWNVLEKT EEAEKTPVGSCFLAQPESGRRAEYS PCRGNTLSRIYVENDFSWDKRYCEA GFSSVVTQAGELVLGAPGGYYFLGL LAQAPVADIFSSYRPGILLWHVSSQ SLSFDSSNPEYFDGYWGYSVAVGEF DGDLNTTEYVVGAPTWSWTLGAVEI LDSYYQRLHRLRGEQMASYFGHSVA VTDVNGDGRHDLLVGAPLYMESRAD RKLAEVGRVYLFLQPRGPHALGAPS LLLTGTQLYGRFGSAIAPLGDLDRD GYNDIAVAAPYGGPSGRGQVLVFLG QSEGLRSRPSQVLDSPFPTGSAFGF SLRGAVDIDDNGYPDLIVGAYGANQ VAVYRAQPVVKASVQLLVQDSLNPA VKSCVLPQTKTPVSCFNIQMCVGAT GHNIPQKLSLNAELQLDRQKPRQGR RVLLLGSQQAGTTLNLDLGGKHSPI CHTTMAFLRDEADFRDKLSPIVLSL NVSLPPTEAGMAPAVVLHGDTHVQE QTRIVLDCGEDDVCVPQLQLTASVT GSPLLVGADNVLELQMDAANEGEGA YEAELAVHLPQGAHYMRALSNVEGF ERLICNQKKENETRVVLCELGNPMK KNAQIGIAMLVSVGNLEEAGESVSF QLQIRSKNSQNPNSKIVLLDVPVRA EAQVELRGNSFPASLVVAAEEGERE QNSLDSWGPKVEHTYELHNNGPGTV NGLHLSIHLPGQSQPSDLLYILDIQ PQGGLQCFPQPPVNPLKVDWGLPIP SPSPIHPAHHKRDRRQIFLPEPEQP SRLQDPVLVSCDSAPCTVVQCDLQE MARGQRAMVTVLAFLWLPSLYQRPL DQFVLQSHAWFNVSSLPYAVPPLSL PRGEAQVWTQLLRALEERAIPIWWV LVGVLGGLLLLTILVLAMWKVGFFK RNRPPLEEDDEEGETRTRPLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
