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Recombinant Human JAG1 Protein, MYC/DDK-tagged

Cat.No. : JAG1-792H
Product Overview : Recombinant human JAG1 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
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Description : The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 133.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : jagged 1[ Homo sapiens ]
Official Symbol : JAG1
Synonyms : AGS; AHD; AWS; CD339; HJ1; JAGL1
Gene ID : 182
mRNA Refseq : NM_000214.2
Protein Refseq : NP_000205
UniProt ID : P78504

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How might knowledge of JAG1 protein be applied in the field of regenerative medicine? 12/26/2020

Understanding the role of JAG1 in tissue regeneration and repair may lead to advances in regenerative medicine by promoting controlled cell differentiation.

Are there any clinical tests available for detecting JAG1 mutations in patients? 09/10/2019

Yes, genetic testing can be performed to identify JAG1 mutations in individuals suspected of having Alagille syndrome or related conditions.

Are there any targeted therapies or treatments related to the JAG1 protein for Alagille syndrome? 11/06/2017

Currently, there are no specific targeted therapies for JAG1-related conditions. Treatment typically focuses on managing symptoms and complications.

Are there any clinical trials currently investigating JAG1-related therapies or treatments? 09/05/2017

Some clinical trials may be exploring therapies or treatments related to JAG1 in the context of specific medical conditions, but it's essential to check for the most up-to-date information.

Can JAG1 be a target for cancer therapy? 05/09/2016

Yes, JAG1 is being investigated as a potential target for cancer therapy, as its role in the Notch pathway can influence cell proliferation and tumor growth.

Customer Reviews (3)

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Reviews
06/24/2021

    When used in Western blotting experiments, the JAG1 protein produces distinct protein bands, allowing for easy visualization and interpretation.

    08/29/2020

      Its resistance to degradation and denaturation allows for longer storage times and repeated use without compromising its performance or functionality.

      04/04/2016

        JAG1 protein is known for its stability and robustness, making it suitable for a wide range of experimental conditions.

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