Recombinant Human KAT2A(497-662) Protein

• Cat.No.: KAT2A-121H
• Product Overview: Recombinant human KAT2A (GCN5L2), amino acids 497-662, expressed in E.coli. Purified using immobilised metal affinity chromatography.

Specification

• Description: KAT2A, also known as GCN5L2 (general control of amino acid synthesis protein 5-like 2), is an epigenetic protein that functions as a histone acetyltransferase (HAT). It is responsible for adding acetyl groups to specific lysine residues on histones, leading to the formation of euchromatin and activation of gene expression. KAT2A is widely expressed in many tissues and is important for normal development and cellular function. It is involved in various biological processes, including transcriptional regulation, DNA damage response, and cell cycle progression. Aberrant KAT2A activity has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular diseases. KAT2A inhibitors are being developed for therapeutic purposes, and understanding its function is important for developing new therapies.
• Source: E. coli
• Species: Human
• Protein length: 497-662 aa
• Form: 1mg/ml of enzyme in 5mM Tris/HCl pH7.4, 250mM NaCl, 50% Glycerol. Frozen solution.
• Molecular Mass: 19.3 kDa
• AA Sequence: 1 GSGIIEFHVI GNSLTPKANR RVLLWLVGLQ NVFSHQLPRM PKEYIARLVF 51 DPKHKTLALI KDGRVIGGIC FRMFPTQGFT EIVFCAVTSN EQVKGYGTHL 101 MNHLKEYHIK HNILYFLTYA DEYAIGYFKK QGFSKDIKVP KSRYLGYIKD 151 YEGATLMECE LNPRIPYT
• Applications: Drug Discovery & Development
• Storage: 1 year at -70 centigrade.
• Handling Advice: Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into prechilled micro-centrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 centigrade.
• Use/Stability: Stable for 1 year at -70 centigrade from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.

Gene Information

• Gene Name: KAT2A lysine acetyltransferase 2A [ Homo sapiens (human) ]
• Official Symbol: KAT2A
• Synonyms: KAT2A; lysine acetyltransferase 2A; GCN5; hGCN5; GCN5L2; PCAF-b
• Gene ID: 2648
• mRNA Refseq: NM_021078.3
• Protein Refseq: NP_066564.2
• MIM: 602301
• UniProt ID: Q92830