Recombinant Human KCNAB2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: KCNAB2-3710H
• Product Overview: KCNAB2 MS Standard C13 and N15-labeled recombinant protein (NP_742128) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 39.1 kDa
• AA Sequence: MYPESTTGSPARLSLRQTGSPGMIY RNLGKSGLRVSCLGLGTWVTFGGQI TDEMAEQLMTLAYDNGINLFDTAEV YAAGKAEVVLGNIIKKKGWRRSSLV ITTKIFWGGKAETERGLSRKHIIEG LKASLERLQLEYVDVVFANRPDPNT PMEETVRAMTHVINQGMAMYWGTSR WSSMEIMEAYSVARQFNLTPPICEQ AEYHMFQREKVEVQLPELFHKIGVG AMTWSPLACGIVSGKYDSGIPPYSR ASLKGYQWLKDKILSEEGRRQQAKL KELQAIAERLGCTLPQLAIAWCLRN EGVSSVLLGASNADQLMENIGAIQV LPKLSSSIIHEIDSILGNKPYSKKD YRSTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: KCNAB2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 [ Homo sapiens (human) ]
• Official Symbol: KCNAB2
• Synonyms: KCNAB2; potassium voltage-gated channel, shaker-related subfamily, beta member 2; voltage-gated potassium channel subunit beta-2; AKR6A5; HKvbeta2.1; HKvbeta2.2; KCNA2B; K+ channel beta-2 subunit; K(+) channel subunit beta-2; potassium channel shaker chain beta 2; HKvbeta2; KV-BETA-2; MGC117289
• Gene ID: 8514
• mRNA Refseq: NM_172130
• Protein Refseq: NP_742128
• MIM: 601142
• UniProt ID: Q13303