Recombinant Human KDM4D Protein, His-tagged KDM4D-015H

Recombinant Human KDM4D Protein, His-tagged

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Recombinant Human KDM4D Protein, His-tagged

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Cat.No. : KDM4D-015H
Product Overview : Recombinant Human KDM4D protein with a N-terminal His-tag was expressed in E. coli
Description : This gene encodes a methylation of lysine residues in core histones and plays a critical role in regulating gene expression. Jumonji domain containing 2D (JMJD2D) catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residue 9 (me 2/3), leading to transcriptional repression and activation, respectively. Like other JmjC protein hydroxylase family members, JMJD2D is an α-ketoglutarate-dependent Fe (II) oxygenase. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylase inhibitors may have the capacity to be anticancer agents.
Source : E. coli
Species : Human
Tag : His
Molecular Mass : 42.7 kDa
Purity : ≥75% estimated by SDS-PAGE
Unit Definition : One unit of activity is defined as the amount of enzyme required to produce 1 nmol of formaldehyde at 37 centigrade in 50 mM HEPES, pH 7.4, containing 0.05% Tween 20, 0.1 mM sodium L-ascorbate, 10 µM ferrous ammonium sulfate, 0.5 mM NAD +, and 50 µM disodium oxoglutarate.
Stability : ≥ 6 months
Storage : -80 centigrade
Storage Buffer : A solution in 50 mM HEPES, pH 7.4, with 150 mM sodium chloride and 20% glycerol
Shipping : Dry ice in continental US, may vary elsewhere.
SDS-PAGE analysis of KDM4D :

Lane 1: MW ladder
Lane 2: JMJD2D (1 µg)
Lane 3: JMJD2D (2 µg)
Lane 4: JMJD2D (4 µg)
Lane 5: JMJD2D (6 µg)

Activity of KDM4D :

Gene Name : KDM4D lysine demethylase 4D [ Homo sapiens (human) ]
Official Symbol : KDM4D
Synonyms : KDM4D; lysine demethylase 4D; JMJD2D; lysine-specific demethylase 4D; [histone H3]-trimethyl-L-lysine(9) demethylase 4D;
jmjC domain-containing histone demethylation protein 3D; jumonji domain containing 2D; lysine (K)-specific demethylase 4D; EC 1.14.11.66
Gene ID : 55693
mRNA Refseq : NM_018039
Protein Refseq : NP_060509
MIM : 609766
UniProt ID : Q6B0I6

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