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Recombinant Human KLHL12 Protein, GST/His-tagged

Cat.No. : KLHL12-615H
Product Overview : Recombinant human KLHL12 protein, fused to GST at N-terminusand His at C-terminusand, was expressed in E. coli.
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  • Gene Information
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Description : This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
Source : E. coli
Species : Human
Tag : GST/His
Form : 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.
Molecular Mass : 91.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : kelch like family member 12[ Homo sapiens ]
Official Symbol : KLHL12
Synonyms : C3IP1; DKIR
Gene ID : 59349
mRNA Refseq : NM_021633.2
Protein Refseq : NP_067646.1
MIM : 614522
UniProt ID : Q53G59

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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