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Recombinant Human KNG1 Protein, MYC/DDK-tagged

Cat.No. : KNG1-687H
Product Overview : Recombinant human KNG1 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
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Description : (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting. [UniProtKB/Swiss-Prot Function]
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 47.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : kininogen 1[ Homo sapiens ]
Official Symbol : KNG1
Synonyms : BDK; BK; KNG
Gene ID : 3827
mRNA Refseq : NM_000893.3
Protein Refseq : NP_000884.1
MIM : 612358
UniProt ID : P01042

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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07/26/2021

    Utilizing protein reagents reduces material consumption in experiments, resulting in resource conservation.

    05/09/2019

      The usage method of protein reagents is flexible, adapting to various experimental requirements.

      01/06/2018

        The precise and reliable results achieved by employing protein reagents make them highly favored in scientific research.

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