Recombinant Human LIPA Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | LIPA-6304H |
Product Overview : | LIPA MS Standard C13 and N15-labeled recombinant protein (NP_000226) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 45.4 kDa |
AA Sequence : | MKMRFLGLVVCLVLWPLHSEGSGGK LTALDPETNMNVSEIISYWGFPSEE YLVETEDGYILCLNRIPHGRKNHSD KGPKPVVFLQHGLLADSSNWVTNLA NSSLGFILADAGFDVWMGNSRGNTW SRKHKTLSVSQDEFWAFSYDEMAKY DLPASINFILNKTGQEQVYYVGHSQ GTTIGFIAFSQIPELAKRIKMFFAL GPVASVAFCTSPMAKLGRLPDHLIK DLFGDKEFLPQSAFLKWLGTHVCTH VILKELCGNLCFLLCGFNERNLNMS RVDVYTTHSPAGTSVQNMLHWSQAV KFQKFQAFDWGSSAKNYFHYNQSYP PTYNVKDMLVPTAVWSGGHDWLADV YDVNILLTQITNLVFHESIPEWEHL DFIWGLDAPWRLYNKIINLMRKYQT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | LIPA lipase A, lysosomal acid type [ Homo sapiens (human) ] |
Official Symbol : | LIPA |
Synonyms : | LIPA; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase/cholesteryl ester hydrolase; CESD; LAL; Wolman disease; sterol esterase; cholesteryl esterase; lysosomal acid lipase; cholesterol ester hydrolase; acid cholesteryl ester hydrolase; |
Gene ID : | 3988 |
mRNA Refseq : | NM_000235 |
Protein Refseq : | NP_000226 |
MIM : | 613497 |
UniProt ID : | P38571 |
Products Types
◆ Recombinant Protein | ||
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LIPA-2343R | Recombinant Rhesus Macaque LIPA Protein, His (Fc)-Avi-tagged | +Inquiry |
LIPA-627H | Recombinant Human LIPA Protein (22-399 aa), GST-tagged | +Inquiry |
LIPA-2158H | Recombinant Human LIPA Protein (22-399 aa), His-tagged | +Inquiry |
◆ Lysates | ||
LIPA-4727HCL | Recombinant Human LIPA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionLIPA protein deficiency impairs the breakdown of cholesterol esters and triglycerides, leading to their accumulation in various tissues and organs.
Diagnosis of LIPA protein deficiency is typically made through genetic testing and measurement of LIPA enzyme activity in blood samples.
Patients with LIPA protein deficiency are often advised to follow a low-fat, high-carbohydrate diet to help manage their lipid levels.
LIPA protein deficiency can result in the accumulation of cholesterol esters and triglycerides in the liver, leading to liver damage and dysfunction.
Yes, researchers are actively studying LIPA protein deficiency and potential therapeutic approaches, including gene therapy and novel enzyme replacement strategies.
Customer Reviews (3)
Write a reviewIts reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.
The reliable performance of the LIPA protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.
Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.
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