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Recombinant Human LIPA Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : LIPA-6304H
Product Overview : LIPA MS Standard C13 and N15-labeled recombinant protein (NP_000226) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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  • Gene Information
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Description : This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 45.4 kDa
AA Sequence : MKMRFLGLVVCLVLWPLHSEGSGGK LTALDPETNMNVSEIISYWGFPSEE YLVETEDGYILCLNRIPHGRKNHSD KGPKPVVFLQHGLLADSSNWVTNLA NSSLGFILADAGFDVWMGNSRGNTW SRKHKTLSVSQDEFWAFSYDEMAKY DLPASINFILNKTGQEQVYYVGHSQ GTTIGFIAFSQIPELAKRIKMFFAL GPVASVAFCTSPMAKLGRLPDHLIK DLFGDKEFLPQSAFLKWLGTHVCTH VILKELCGNLCFLLCGFNERNLNMS RVDVYTTHSPAGTSVQNMLHWSQAV KFQKFQAFDWGSSAKNYFHYNQSYP PTYNVKDMLVPTAVWSGGHDWLADV YDVNILLTQITNLVFHESIPEWEHL DFIWGLDAPWRLYNKIINLMRKYQT RTRPLEQKLISEEDLAANDILDYKD DDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : LIPA lipase A, lysosomal acid type [ Homo sapiens (human) ]
Official Symbol : LIPA
Synonyms : LIPA; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase/cholesteryl ester hydrolase; CESD; LAL; Wolman disease; sterol esterase; cholesteryl esterase; lysosomal acid lipase; cholesterol ester hydrolase; acid cholesteryl ester hydrolase;
Gene ID : 3988
mRNA Refseq : NM_000235
Protein Refseq : NP_000226
MIM : 613497
UniProt ID : P38571

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does LIPA protein deficiency affect lipid metabolism? 04/30/2021

LIPA protein deficiency impairs the breakdown of cholesterol esters and triglycerides, leading to their accumulation in various tissues and organs.

How is LIPA protein deficiency diagnosed? 09/14/2020

Diagnosis of LIPA protein deficiency is typically made through genetic testing and measurement of LIPA enzyme activity in blood samples.

Are there any specific dietary recommendations for individuals with LIPA protein deficiency? 03/23/2020

Patients with LIPA protein deficiency are often advised to follow a low-fat, high-carbohydrate diet to help manage their lipid levels.

How does LIPA protein deficiency affect the liver? 01/06/2019

LIPA protein deficiency can result in the accumulation of cholesterol esters and triglycerides in the liver, leading to liver damage and dysfunction.

Are there any ongoing research efforts focused on LIPA protein and its clinical applications? 05/19/2016

Yes, researchers are actively studying LIPA protein deficiency and potential therapeutic approaches, including gene therapy and novel enzyme replacement strategies.

Customer Reviews (3)

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Reviews
03/02/2019

    Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.

    01/18/2018

      The reliable performance of the LIPA protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.

      03/05/2017

        Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.

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