Recombinant Human LRP5 Protein, MYC/DDK-tagged

• Cat.No.: LRP5-849H
• Product Overview: Recombinant human LRP5 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Description: This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 179 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: LDL receptor related protein 5[ Homo sapiens ]
• Official Symbol: LRP5
• Synonyms: BMND1; EVR1; EVR4; HBM; LR3; LRP-5; LRP7; OPPG; OPS; OPTA1; VBCH2
• Gene ID: 4041
• mRNA Refseq: NM_002335.2
• Protein Refseq: NP_002326
• MIM: 603506
• UniProt ID: O75197