| Description : |
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
91.4 kDa |
| AA Sequence : |
MALLRDVSLQDPRDRFELLQRVGAG TYGDVYKARDTVTSELAAVKIVKLD PGDDISSLQQEITILRECRHPNVVA YIGSYLRNDRLWICMEFCGGGSLQE IYHATGPLEERQIAYVCREALKGLH HLHSQGKIHRDIKGANLLLTLQGDV KLADFGVSGELTASVAKRRSFIGTP YWMAPEVAAVERKGGYNELCDVWAL GITAIELGELQPPLFHLHPMRALML MSKSSFQPPKLRDKTRWTQNFHHFL KLALTKNPKKRPTAEKLLQHPFTTQ QLPRALLTQLLDKASDPHLGTPSPE DCELETYDMFPDTIHSRGQHGPAER TPSEIQFHQVKFGAPRRKETDPLNE PWEEEWTLLGKEELSGSLLQSVQEA LEERSLTIRSASEFQELDSPDDTMG TIKRAPFLGPLPTDPPAEEPLSSPP GTLPPPPSGPNSSPLLPTAWATMKQ REDPERSSCHGLPPTPKVHMGACFS KVFNGCPLRIHAAVTWIHPVTRDQF LVVGAEEGIYTLNLHELHEDTLEKL ISHRCSWLYCVNNVLLSLSGKSTHI WAHDLPGLFEQRRLQQQVPLSIPTN RLTQRIIPRRFALSTKIPDTKGCLQ CRVVRNPYTGATFLLAALPTSLLLL QWYEPLQKFLLLKNFSSPLPSPAGM LEPLVLDGKELPQVCVGAEGPEGPG CRVLFHVLPLEAGLTPDILIPPEGI PGSAQQVIQVDRDTILVSFERCVRI VNMQGEPTATLAPELTFDFPIETVV CLQDSVLAFWSHGMQGRSLDTNEVT QEITDETRIFRVLGAHRDIILESIP TDNPEAHSNLYILTGHQSTYTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
