Description : |
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
77.5 kDa |
AA Sequence : |
MAERESGGLGGGAASPPAASPFLGL HIASPPNFRLTHDISLEEFEDEDLS EITDECGISLQCKDTLSLRPPRAGL LSAGGGGAGSRLQAEMLQMDLIDAT GDTPGAEDDEEDDDEERAARRPGAG PPKAESGQEPASRGQGQSQGQSQGP GSGDTYRPKRPTTLNLFPQVPRSQD TLNNNSLGKKHSWQDRVSRSSSPLK TGEQTPPHEHICVSDELSPQSGPAP TTGRGTSTDSPCRRSTATQMAPPGG PPAATPGGRGHSHRDRIHYQADVRL EATEEIYLTPVQRPPDAAEPTSAFL PPTESRMSVSSDPDPAAYPSTAGRP HPSISEEEEGFDCMSSPERAEPPGG GWRGSLGEPPPPPRASLSSDTSALS YDSVKYTLVVDEHAQLELVSLRPCF GDYSDESDSATVYDNCASVSSPYES AIGEEYEEAPRPQPPACLSEDSTPD EPDVHFSKKFLNVFMSGRSRSSSAE SFGLFSCIINGEEQEQTHRAIFRFV PRHEDELELEVDDPLLVELQAEDYW YEAYNMRTGARGVFPAYYAIEVTKE PEHMAALAKNSDWVDQFRVKFLGSV QVPYHKGNDVLCAAMQKIATTRRLT VHFNPPSSCVLEINVRGVKIGVKAD DSQEAKGNKCSHFFQLKNISFCGYH PKNNKYFGFITKHPADNRFACHVFV SEDSTKALAESVGRAFQQFYKQFVE YTCPTEDIYLETRTRPLEQKLISEE DLAANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |