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Recombinant Human MFGE8 Protein, MYC/DDK-tagged

Cat.No. : MFGE8-1242H
Product Overview : Recombinant human MFGE8 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
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Description : This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 42.9 kDa
Purity : >50 ug/mL as determined by microplate BCA method
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : MFGE8 milk fat globule-EGF factor 8 protein [ Homo sapiens ]
Official Symbol : MFGE8
Synonyms : BA46; EDIL1; HMFG; hP47; HsT19888; MFG-E8; MFGM; OAcGD3S; SED1; SPAG10
Gene ID : 4240
mRNA Refseq : NM_001114614
Protein Refseq : NP_001108086
MIM : 602281
UniProt ID : Q08431

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there a relationship between MFGE8's structure and function? 01/13/2023

The structure of MFGE8 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.

Does MFGE8 interact with other proteins? 11/16/2022

MFGE8 can interact with a variety of other proteins, including Caspase-3, Caspase-8, EGFR, etc. These interactions enable it to regulate processes such as apoptosis, signal transduction, and cell adhesion.

What will future research on MFGE8 focus on? 05/18/2022

Future studies of MFGE8 may focus on the following aspects: its structure-function relationship, mechanisms of interaction with other proteins, regulatory mechanisms in cells, and potential therapeutic applications. At the same time, the study of MFGE8's interaction with specific signal transduction pathways and its regulatory effect on cell growth and differentiation will also become one of the future research priorities.

What are the treatment strategies for MFGE8? 07/29/2021

Therapeutic strategies for MFGE8 may include regulating its expression level, inhibiting its interaction with other proteins, and promoting or inhibiting its function. These methods may have potential applications in the treatment of cancer, neurodegenerative diseases, and autoimmune diseases.

Does MFGE8 have a role in neurodegenerative diseases? 07/07/2021

In neurodegenerative diseases, MFGE8 may influence the survival and death processes of neurons by regulating apoptosis and signal transduction. It could be a potential target for the treatment of neurodegenerative diseases.

What factors should be considered in drug development for MFGE8? 08/25/2020

Drug development against MFGE8 needs to consider its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.

Customer Reviews (3)

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Reviews
08/08/2022

    It has high application effect and safety in clinical treatment.

    10/08/2021

      MFGE8 has a high resolution in Western blots, which can distinguish similar protein molecular weights.

      11/09/2020

        Good stability and activity retention during long-term storage.

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