Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human MICA Protein, MYC/DDK-tagged

Cat.No. : MICA-1235H
Product Overview : Recombinant human MICA protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 40.7 kDa
Purity : >50 ug/mL as determined by microplate BCA method
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : MICA MHC class I polypeptide-related sequence A [ Homo sapiens ]
Official Symbol : MICA
Synonyms : MIC-A; PERB11.1
Gene ID : 100507436
mRNA Refseq : NM_000247
Protein Refseq : NP_000238
MIM : 600169
UniProt ID : Q29983

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does MICA relate to infectious diseases? 05/01/2022

MICA expression can change during viral infections and influence the immune response to the pathogen.

How can MICA protein be targeted in cancer therapy? 09/01/2021

Monoclonal antibodies and immunotherapies can target MICA on cancer cells, making them more susceptible to immune system attack.

Are there diagnostic tests that measure MICA expression in cancer patients? 11/10/2019

Yes, tests like immunohistochemistry and flow cytometry can measure MICA expression on tumor cells and help in cancer diagnosis and treatment planning.

What are the implications of MICA expression in autoimmune diseases? 08/27/2018

Altered MICA expression has been associated with some autoimmune diseases, such as rheumatoid arthritis, suggesting a potential role in disease development.

Can MICA polymorphisms affect the outcome of organ transplantation? 05/09/2016

Yes, MICA polymorphisms can influence the success of organ transplantation by affecting the compatibility between donor and recipient.

Customer Reviews (3)

Write a review
Reviews
01/16/2022

    when utilized in Western Blotting experiments, the MICA protein has consistently produced distinct and well-defined protein bands, facilitating clear and accurate interpretation of results.

    01/18/2020

      I have successfully implemented the MICA protein in protein electron microscopy structure analysis, where its attributes have greatly aided in elucidating complex molecular structures.

      03/23/2016

        Considering its remarkable performance across multiple assays, I wholeheartedly endorse the usage of the MICA protein in various research studies.

        Ask a Question for All MICA Products

        Required fields are marked with *

        My Review for All MICA Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends