Recombinant Human MICA Protein, MYC/DDK-tagged
Cat.No. : | MICA-1235H |
Product Overview : | Recombinant human MICA protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol. |
Molecular Mass : | 40.7 kDa |
Purity : | >50 ug/mL as determined by microplate BCA method |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | MICA MHC class I polypeptide-related sequence A [ Homo sapiens ] |
Official Symbol : | MICA |
Synonyms : | MIC-A; PERB11.1 |
Gene ID : | 100507436 |
mRNA Refseq : | NM_000247 |
Protein Refseq : | NP_000238 |
MIM : | 600169 |
UniProt ID : | Q29983 |
Products Types
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMICA expression can change during viral infections and influence the immune response to the pathogen.
Monoclonal antibodies and immunotherapies can target MICA on cancer cells, making them more susceptible to immune system attack.
Yes, tests like immunohistochemistry and flow cytometry can measure MICA expression on tumor cells and help in cancer diagnosis and treatment planning.
Altered MICA expression has been associated with some autoimmune diseases, such as rheumatoid arthritis, suggesting a potential role in disease development.
Yes, MICA polymorphisms can influence the success of organ transplantation by affecting the compatibility between donor and recipient.
Customer Reviews (3)
Write a reviewwhen utilized in Western Blotting experiments, the MICA protein has consistently produced distinct and well-defined protein bands, facilitating clear and accurate interpretation of results.
I have successfully implemented the MICA protein in protein electron microscopy structure analysis, where its attributes have greatly aided in elucidating complex molecular structures.
Considering its remarkable performance across multiple assays, I wholeheartedly endorse the usage of the MICA protein in various research studies.
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