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Active Recombinant Human MIF Protein, His-tagged

Cat.No. : MIF-736H
Product Overview : Recombinant Human MIF fused with His tag at N-terminal was expressed in Hi-5 Insect cells.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.
Source : Hi-5 Insect cells
Species : Human
Tag : His
Form : Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer, 100mM NaCl, pH 7.2
Bio-activity : Determined by its ability to inhibit monocyte migration.
Molecular Mass : 15 kDa
AA Sequence : HHHHHHHHAMPMFIVNTNVPRASVP DGFLSELTQQLAQATGKPPQYIAVH VVPDQLMAFGGSSEPCALCSLHSIG KIGGAQNRSYSKLLCGLLAERLRIS PDRVYINYYDMNAANVGWNNSTFA
Endotoxin : Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
Purity : >95% as determined by SDS-PAGE and Coomassie blue staining
Concentration : Resuspend the protein in the desired concentration in proper buffer
Gene Name : MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) [ Homo sapiens ]
Official Symbol : MIF
Synonyms : MIF; macrophage migration inhibitory factor (glycosylation-inhibiting factor); GLIF; macrophage migration inhibitory factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase; phenylpyruvate tautomerase; MMIF;
Gene ID : 4282
mRNA Refseq : NM_002415
Protein Refseq : NP_002406
MIM : 153620
UniProt ID : P14174

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does MIF contribute to autoimmune diseases? 07/30/2022

MIF can promote inflammation and immune responses, contributing to autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus.

How does MIF influence neuroinflammation? 10/01/2021

MIF is involved in the regulation of neuroinflammation and has implications in neurodegenerative diseases like Alzheimer's.

What are some conditions where MIF is implicated in clinical applications? 12/22/2019

MIF is implicated in conditions like autoimmune diseases, sepsis, and cancer.

Can MIF be a potential therapeutic target in autoimmune diseases? 08/20/2019

Yes, targeting MIF with drugs or antibodies is being explored as a potential treatment for autoimmune diseases.

What are some other clinical applications of MIF? 02/26/2019

MIF is also studied in the context of cardiovascular diseases, neuroinflammation, and wound healing.

Customer Reviews (3)

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Reviews
12/05/2022

    The cost-effectiveness of the MIF protein, competitive pricing, and the availability of bulk purchase options provided by the manufacturer also align with my budget considerations, allowing me to optimize my resources.

    10/13/2016

      the manufacturer's commitment to delivering the MIF protein in a timely manner is greatly appreciated.

      06/06/2016

        the excellent technical support provided by the manufacturer is of immense value to me.

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