Recombinant Human MMP1 Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | MMP1-4231H |
Product Overview : | MMP1 MS Standard C13 and N15-labeled recombinant protein (NP_002412) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 54 kDa |
AA Sequence : | MHSFPPLLLLLFWGVVSHSFPATLE TQEQDVDLVQKYLEKYYNLKNDGRQ VEKRRNSGPVVEKLKQMQEFFGLKV TGKPDAETLKVMKQPRCGVPDVAQF VLTEGNPRWEQTHLTYRIENYTPDL PRADVDHAIEKAFQLWSNVTPLTFT KVSEGQADIMISFVRGDHRDNSPFD GPGGNLAHAFQPGPGIGGDAHFDED ERWTNNFREYNLHRVAAHELGHSLG LSHSTDIGALMYPSYTFSGDVQLAQ DDIDGIQAIYGRSQNPVQPIGPQTP KACDSKLTFDAITTIRGEVMFFKDR FYMRTNPFYPEVELNFISVFWPQLP NGLEAAYEFADRDEVRFFKGNKYWA VQGQNVLHGYPKDIYSSFGFPRTVK HIDAALSEENTGKTYFFVANKYWRY DEYKRSMDPGYPKMIAHDFPGIGHK VDAVFMKDGFFYFFHGTRQYKFDPK TKRILTLQKANSWFNCRKNTRTRPL EQKLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | MMP1 matrix metallopeptidase 1 [ Homo sapiens (human) ] |
Official Symbol : | MMP1 |
Synonyms : | MMP1; matrix metallopeptidase 1 (interstitial collagenase); CLG, matrix metalloproteinase 1 (interstitial collagenase); interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1; CLG; CLGN; |
Gene ID : | 4312 |
mRNA Refseq : | NM_002421 |
Protein Refseq : | NP_002412 |
MIM : | 120353 |
UniProt ID : | P03956 |
Products Types
◆ Recombinant Protein | ||
MMP1-5412H | Active Recombinant Human MMP1 Protein | +Inquiry |
MMP1-1115R | Recombinant Rabbit MMP1 Protein, His-tagged | +Inquiry |
MMP1-2535H | Recombinant Human MMP1 protein(111-290 aa), N-MBP & C-His-tagged | +Inquiry |
MMP1-568H | Recombinant Human MMP1 Protein, His-tagged | +Inquiry |
MMP1-2536H | Recombinant Human MMP1 protein(20-469 aa), N-MBP & C-His-tagged | +Inquiry |
◆ Native Protein | ||
MMP1-45H | Native Human MMP-1 | +Inquiry |
◆ Lysates | ||
MMP1-2884HCL | Recombinant Human MMP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMMP1 is involved in the remodeling of tissue during wound healing by facilitating the breakdown of damaged extracellular matrix components.
Inhibiting MMP1 activity is being explored as a potential therapeutic strategy to impede cancer progression and metastasis.
MMP1 plays a key role in tissue remodeling by degrading collagen, a major component of the extracellular matrix, which is essential for processes like wound healing.
MMP1 overexpression is associated with various diseases, including rheumatoid arthritis, atherosclerosis, and certain types of cancer.
High MMP1 levels have been correlated with poor prognosis in certain cancer types, making it a potential biomarker for predicting disease outcomes.
Customer Reviews (3)
Write a reviewThe manufacturer can offer technical support and expertise to guide researchers through the experimental process.
The manufacturer can play a vital role in supporting and optimizing the research process.
This guarantees that the protein is reliable, consistent, and suitable for experiments, reducing variability and enhancing the reproducibility of findings.
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