Active Recombinant Human MMP2 protein
Cat.No. : | MMP2-201H |
Product Overview : | Recombinant Human MMP2 was expressed in E. coli. |
- Specification
- Gene Information
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Description : | MMP-2 belongs to a family of endoproteases which need calcium and zinc in order to exert their catalytic capability (extracellular matrix remodeling). The elevated expression of these enzymes has been linked to many degenerative disorders, such as arthritis, cancer metastasis and skeletal growth-plate disorders. It has been shown that MMP-2 associates with many connective tissue cells as well as neutrophils, macrophages and monocytes. |
Source : | E. coli |
Species : | Human |
Form : | Supplied as a 0.2 μm filtered solution in Tris, CaCl2, NaCl and Brij35 |
Bio-activity : | The ED (50) was determined by the dose-dependent proliferation of immortalized human pulmonary fibroblasts cells and was found to be <0.05ng/mL. |
Molecular Mass : | 62.0 kDa |
Endotoxin : | <1.0 EU/μg of recombinant protein as determined by the LAL method. |
Purity : | 95% |
Applications : | Cell Assay |
Storage : | The lyophilized protein is stable for at least one year from date of receipt at -70 centigrade. Upon reconstitution, this cytokine can be stored in working aliquots at 2 centigrade- 8 centigrade for one month, or at -20 centigrade for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. |
Gene Name : | MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) [ Homo sapiens ] |
Official Symbol : | MMP2 |
Synonyms : | MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); CLG4, CLG4A, matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase) , matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); 72 kDa type IV collagenase; TBE 1; MMP-2; gelatinase A; 72 kDa gelatinase; collagenase type IV-A; neutrophil gelatinase; matrix metalloproteinase-2; matrix metalloproteinase-II; CLG4; MONA; CLG4A; TBE-1; MMP-II; |
Gene ID : | 4313 |
mRNA Refseq : | NM_001127891 |
Protein Refseq : | NP_001121363 |
MIM : | 120360 |
UniProt ID : | P08253 |
Chromosome Location : | 16q13-q21 |
Pathway : | ATF-2 transcription factor network, organism-specific biosystem; Activation of Matrix Metalloproteinases, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Diabetes pathways, organism-specific biosystem; |
Function : | metal ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding; |
Products Types
◆ Recombinant Protein | ||
MMP2-562H | Recombinant Human MMP2 Protein, MYC/DDK-tagged | +Inquiry |
MMP2-182H | Active Recombinant Human MMP2 Protein, His-tagged | +Inquiry |
Mmp2-1783M | Recombinant Mouse Mmp2 Protein, His-tagged | +Inquiry |
MMP2-657R | Recombinant Rat MMP2 Protein (110-662 aa), His-SUMO-tagged | +Inquiry |
MMP2-03H | Active Recombinant Pre-activated Human MMP2 Protein (110-660) | +Inquiry |
◆ Native Protein | ||
MMP2-8455M | Native Mouse MMP2 | +Inquiry |
MMP2-29475TH | Native Human MMP2 | +Inquiry |
MMP2-46H | Native Human MMP-2 | +Inquiry |
◆ Lysates | ||
MMP2-2380HCL | Recombinant Human MMP2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0320C | MMP2 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe activity of MMP2 is regulated by inhibitors and antibodies against it to inhibit tumor metastasis and invasion.
MMP2 interacts with some transfer factors, such as VEGF and EGF, to promote tumor metastasis and invasion.
Inhibitors of MMP2 can be used as potential drug targets for the treatment of tumors, cardiovascular diseases and other related diseases.
MMP2 interacts with tumor cells, immune cells, blood vessels, etc. in the tumor microenvironment to affect tumor progression and treatment effect.
It is involved in important processes such as morphogenesis, organ development and intraembryonic lymphatic vessel formation during embryonic development.
Mutations in MMP2 may affect its protein structure and function, leading to the occurrence and progression of related diseases.
Customer Reviews (3)
Write a reviewThe solubility and ion exchange ability are very good, which is convenient for subsequent experimental treatment and purification.
Kinetic parameters such as enzymatic reaction rate and binding affinity were tested in the early stage, and it was found that the protein performed well.
MMP2 products undergo strict quality control to ensure the consistency and stability of each batch.
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