Active Recombinant Human MRAS (Q71L) Protein, His-tagged
Cat.No. : | MRAS-703H |
Product Overview : | Recombinant Human MRAS protein (NM_012219,Q71L) was expressed in E. coli with His tag. |
- Specification
- Gene Information
- Related Products
Description : | Ras proteins are members of the superfamily of small GTP-binding proteins that function as molecular switches controlling a variety of signaling and transport pathways. The Ras family of GTP-binding proteins consists of the classical Ras (Ha-, K-, and N-), R-Ras, Rap1, Rap2, Ral, Rheb, Rin, Rit, TC21/R-Ras2, and M-Ras/R-Ras3 (M-Ras). Stimulation of Ba/F3-Fms cells with either IL-3 or CSF-1 resulted in efficient activation of both K-Ras 4B and M-Ras. Stimulation of fibroblasts with EGF also led to more efficient activation of K-Ras 4B than of H-Ras or N-Ras, and the activation of M-Ras was very strong. An S27N mutant of M-Ras, like the analogous H-Ras S17N mutant, was a dominant inhibitor of activation of the c-fos promoter by constitutively active Src Y527F, suggesting that M-Ras and p21 Ras shared guanine nucleotide exchange factors and are likely to be activated in parallel. M-Ras (Q71L) is a constitutive active mutant of M-Ras. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 25 mM HEPES pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 μM GDP and 50% glycerol |
Bio-activity : | GTPγS binding: >750 mmol/mol. |
Purity : | > 95 % (SDS-PAGE) |
Storage : | Store at -20 centigrade. |
Gene Name : | MRAS muscle RAS oncogene homolog [ Homo sapiens ] |
Official Symbol : | MRAS |
Synonyms : | M-RAs; RRAS3; R-RAS3 |
Gene ID : | 22808 |
mRNA Refseq : | NM_001085049.1 |
Protein Refseq : | NP_001078518.1 |
MIM : | 608435 |
UniProt ID : | O14807 |
Products Types
◆ Recombinant Protein | ||
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◆ Lysates | ||
MRAS-4213HCL | Recombinant Human MRAS 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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