Active Recombinant Human MSTN Protein

• Cat.No.: MSTN-052H
• Product Overview: The mature recombinant human GDF-8 protein (268-376aa) without tag was expressed in E. coli.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals.
• Source: E. coli
• Species: Human
• Bio-activity: The ED50 as determined by the inhibition of the proliferation of MPC-11 cells is < 20ng/mL, corresponding to a Specific Activity of 50,000units/mg.
• Molecular Mass: 12.4 kDa
• Product-Related Proteins: 268-376
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: MSTN myostatin [ Homo sapiens (human) ]
• Official Symbol: MSTN
• Synonyms: MSTN; myostatin; GDF8; MSLHP; growth/differentiation factor 8
• Gene ID: 2660
• mRNA Refseq: NM_005259
• Protein Refseq: NP_005250
• MIM: 601788
• UniProt ID: O14793