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Recombinant Human MTAP Protein, MYC/DDK-tagged

Cat.No. : MTAP-2005H
Product Overview : Recombinant human MTAP protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
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  • Gene Information
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Description : This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 31.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : MTAP methylthioadenosine phosphorylase [ Homo sapiens ]
Official Symbol : MTAP
Synonyms : BDMF; c86fus; DMSFH; DMSMFH; HEL-249; LGMBF; MSAP
Gene ID : 4507
mRNA Refseq : NM_002451
Protein Refseq : NP_002442
MIM : 156540
UniProt ID : Q13126

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can MTAP protein status be used as a predictive biomarker for treatment response? 03/08/2023

Yes, the presence or absence of MTAP is being investigated as a potential predictive biomarker for the response to specific anticancer therapies.

Are there diagnostic tools that leverage MTAP protein status for cancer detection? 01/29/2023

Yes, molecular diagnostic techniques can assess MTAP status in tumors, aiding in cancer diagnosis and prognosis.

Are there challenges associated with targeting MTAP for cancer therapy? 11/07/2022

One challenge is the development of targeted therapies that selectively exploit MTAP deficiency without causing significant side effects in normal cells.

What targeted therapies are being developed based on the understanding of MTAP protein function? 10/26/2022

Researchers are exploring targeted therapies that exploit MTAP deficiency in cancer cells, aiming for more effective and selective treatments.

How does the MTAP protein influence the sensitivity of cancer cells to specific drugs? 10/19/2020

MTAP-deficient cells may be more sensitive to certain chemotherapeutic agents, offering a potential therapeutic advantage in cancer treatment.

Customer Reviews (3)

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Reviews
01/23/2023

    What sets the MTAP protein apart is not only its outstanding quality but also the excellent technical support provided by the manufacturer.

    04/04/2021

      the MTAP protein's versatility extends beyond its proven usefulness in in vitro experiments.

      08/28/2018

        Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the MTAP protein is an invaluable tool for researchers.

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