Recombinant Human NEFL Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | NEFL-526H |
Product Overview : | NEFL MS Standard C13 and N15-labeled recombinant protein (NP_006149) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
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Description : | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 61.5 kDa |
AA Sequence : | MSSFSYEPYYSTSYKRRYVETPRVH ISSVRSGYSTARSAYSSYSAPVSSS LSVRRSYSSSSGSLMPSLENLDLSQ VAAISNDLKSIRTQEKAQLQDLNDR FASFIERVHELEQQNKVLEAELLVL RQKHSEPSRFRALYEQEIRDLRLAA EDATNEKQALQGEREGLEETLRNLQ ARYEEEVLSREDAEGRLMEARKGAD EAALARAELEKRIDSLMDEISFLKK VHEEEIAELQAQIQYAQISVEMDVT KPDLSAALKDIRAQYEKLAAKNMQN AEEWFKSRFTVLTESAAKNTDAVRA AKDEVSESRRLLKAKTLEIEACRGM NEALEKQLQELEDKQNADISAMQDT INKLENELRTTKSEMARYLKEYQDL LNVKMALDIEIAAYRKLLEGEETRL SFTSVGSITSGYSQSSQVFGRSAYG GLQTSSYLMSTRSFPSYYTSHVQEE QIEVEETIEAAKAEEAKDEPPSEGE AEEEEKDKEEAEEEEAAEEEEAAKE ESEEAKEEEEGGEGEEGEETKEAEE EEKKVEGAGEEQAAKKKDTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | NEFL neurofilament light [ Homo sapiens (human) ] |
Official Symbol : | NEFL |
Synonyms : | NEFL; neurofilament, light polypeptide; neurofilament, light polypeptide 68kDa; neurofilament light polypeptide; CMT1F; CMT2E; NF68; NFL; neurofilament subunit NF-L; neurofilament triplet L protein; neurofilament protein, light chain; light molecular weight neurofilament protein; NF-L; FLJ53642; |
Gene ID : | 4747 |
mRNA Refseq : | NM_006158 |
Protein Refseq : | NP_006149 |
MIM : | 162280 |
UniProt ID : | P07196 |
Products Types
◆ Recombinant Protein | ||
NEFL-1292H | Recombinant Human NEFL Protein, His-SUMO/MYC-tagged | +Inquiry |
NEFL-2573H | Recombinant Human NEFL protein(91-510 aa), C-His-tagged | +Inquiry |
NEFL-23H | Recombinant Human NEFL Protein, His-tagged | +Inquiry |
NEFL-2815R | Recombinant Rhesus Macaque NEFL Protein, His (Fc)-Avi-tagged | +Inquiry |
NEFL-2484H | Recombinant Human NEFL Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
NEFL-181B | Native bovine NEFL | +Inquiry |
NFL-01P | Native Pig NFL Protein (549 AA) | +Inquiry |
◆ Lysates | ||
NEFL-3884HCL | Recombinant Human NEFL 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionNEFL is the light chain subunit of neurofilaments, crucial for their assembly and function.
It is a major component of neurofilaments, providing stability and support to axons.
Genetic mutations in NEFL have been linked to Charcot-Marie-Tooth disease and other neuropathies.
NEFL plays a crucial role in maintaining the structure and function of neuronal axons.
NEFL is predominantly expressed in neurons, particularly in the axons.
Therapeutic strategies are being developed to target NEFL aggregation and dysfunction in neurodegenerative diseases.
Abnormal accumulation of NEFL is associated with various neurodegenerative diseases.
Customer Reviews (3)
Write a reviewWorked well, fast shipping.
Satisfied with the quality.
Excellent product, very satisfied.
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