| Description : |
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
50.2 kDa |
| AA Sequence : |
MSLWLGAPVPDIPPDSAVELWKPGA QDASSQAQGGSSCILREEARMPHSA GGTAGVGLEAAEPTALLTRAEPPSE PTEIRPQKRKKGPAPKMLGNELCSV CGDKASGFHYNVLSCEGCKGFFRRS VIKGAHYICHSGGHCPMDTYMRRKC QECRLRKCRQAGMREECVLSEEQIR LKKLKRQEEEQAHATSLPPRASSPP QILPQLSPEQLGMIEKLVAAQQQCN RRSFSDRLRVTPWPMAPDPHSREAR QQRFAHFTELAIVSVQEIVDFAKQL PGFLQLSREDQIALLKTSAIEVMLL ETSRRYNPGSESITFLKDFSYNRED FAKAGLQVEFINPIFEFSRAMNELQ LNDAEFALLIAISIFSADRPNVQDQ LQVERLQHTYVEALHAYVSIHHPHD RLMFPRMLMKLVSLRTLSSVHSEQV FALRLQDKKLPPLLSEIWDVHETRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
