Recombinant Human NRG4 Protein, His/GST-tagged
Cat.No. : | NRG4-365H |
Product Overview : | Recombinant Human NRG4(Met1~Phe62) fused with His/GST tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
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Description : | The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]). |
Source : | E. coli |
Species : | Human |
Tag : | His/GST |
Form : | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
Molecular Mass : | 39.2kDa |
Protein length : | Met1~Phe62 |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | > 95% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Reconstitution : | Reconstitute in PBS or others |
Gene Name : | NRG4 neuregulin 4 [ Homo sapiens ] |
Official Symbol : | NRG4 |
Synonyms : | NRG4; neuregulin 4; pro-neuregulin-4, membrane-bound isoform; HRG4; pro-NRG4; heregulin 4; DKFZp779N0541; DKFZp779N1944; |
Gene ID : | 145957 |
mRNA Refseq : | NM_138573 |
Protein Refseq : | NP_612640 |
MIM : | 610894 |
UniProt ID : | Q8WWG1 |
Products Types
◆ Recombinant Protein | ||
NRG4-07H | Active Recombinant Human NRG4 Protein | +Inquiry |
Nrg4-1861R | Recombinant Rat Nrg4 Protein, His-tagged | +Inquiry |
NRG4-3679H | Recombinant Human NRG4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Nrg4-01M | Active Recombinant Mouse Nrg4 Protein, GST-tagged | +Inquiry |
Nrg4-366M | Recombinant Mouse Nrg4 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
NRG4-1221HCL | Recombinant Human NRG4 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe function of NRG4 can be studied through overexpression techniques, such as the use of gene transfection or viral transduction. These techniques can increase the expression level of NRG4 to observe its effects on cell growth, differentiation, and survival, among other things.
It has a variety of roles in tissues such as the heart, nerves, and muscles, including promoting cell growth, differentiation, and survival, as well as regulating synaptic plasticity and nerve signaling.
In the heart, NRG4 can promote cardiomyocyte growth and survival, maintain cardiomyocyte electrophysiological properties, and regulate cardiac rhythms.
Immunohistochemistry, western blotting, and real-time PCR can be used to detect NRG4 expression levels in tissues and cells. These techniques can be used to assess NRG4 expression in different tissues and cells.
NRG4 activates receptor phosphorylation by interacting with its receptors ErbB3 and ErbB4, which in turn triggers intracellular signaling pathways.
The interaction between NRG4 and other proteins is regulated by a variety of mechanisms, including through the formation of complexes, through interaction motifs at the interface of protein interactions, and by regulating conformational changes of proteins. These interactions can be modulated to achieve specific physiological functions.
Customer Reviews (3)
Write a reviewNRG4 had the intended biological effect in the experiment.
The experimental results using NRG4 are accurate and reliable, and the data are scientific.
NRG4's products have been widely recognized and applied in the research of related fields.
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