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Recombinant Human NRG4 Protein, His/GST-tagged

Cat.No. : NRG4-365H
Product Overview : Recombinant Human NRG4(Met1~Phe62) fused with His/GST tag at N-terminal was expressed in E. coli.
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  • Gene Information
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Description : The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).
Source : E. coli
Species : Human
Tag : His/GST
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 39.2kDa
Protein length : Met1~Phe62
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others
Gene Name : NRG4 neuregulin 4 [ Homo sapiens ]
Official Symbol : NRG4
Synonyms : NRG4; neuregulin 4; pro-neuregulin-4, membrane-bound isoform; HRG4; pro-NRG4; heregulin 4; DKFZp779N0541; DKFZp779N1944;
Gene ID : 145957
mRNA Refseq : NM_138573
Protein Refseq : NP_612640
MIM : 610894
UniProt ID : Q8WWG1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How can the function of NRG4 be studied by overexpression techniques? 12/08/2022

The function of NRG4 can be studied through overexpression techniques, such as the use of gene transfection or viral transduction. These techniques can increase the expression level of NRG4 to observe its effects on cell growth, differentiation, and survival, among other things.

What is the role of NRG4 in tissues such as the heart, nerves, and muscles? 12/03/2021

It has a variety of roles in tissues such as the heart, nerves, and muscles, including promoting cell growth, differentiation, and survival, as well as regulating synaptic plasticity and nerve signaling.

What is the physiological function of NRG4 in the heart? 11/09/2021

In the heart, NRG4 can promote cardiomyocyte growth and survival, maintain cardiomyocyte electrophysiological properties, and regulate cardiac rhythms.

How can I measure the expression level of NRG4 in tissues and cells? 07/07/2021

Immunohistochemistry, western blotting, and real-time PCR can be used to detect NRG4 expression levels in tissues and cells. These techniques can be used to assess NRG4 expression in different tissues and cells.

How does NRG4 interact with target cell surface receptors? 10/13/2020

NRG4 activates receptor phosphorylation by interacting with its receptors ErbB3 and ErbB4, which in turn triggers intracellular signaling pathways.

Is there a regulatory role for the interaction between NRG4 and other proteins? 01/26/2020

The interaction between NRG4 and other proteins is regulated by a variety of mechanisms, including through the formation of complexes, through interaction motifs at the interface of protein interactions, and by regulating conformational changes of proteins. These interactions can be modulated to achieve specific physiological functions.

Customer Reviews (3)

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Reviews
09/08/2022

    NRG4 had the intended biological effect in the experiment.

    08/04/2021

      The experimental results using NRG4 are accurate and reliable, and the data are scientific.

      06/17/2021

        NRG4's products have been widely recognized and applied in the research of related fields.

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