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Recombinant Human NSD2(825-1208) Protein

Cat.No. : NSD2-258H
Product Overview : Recombinant human NSD2, Amino acids 825-1208, expressed in E.coli. Purified using immobilised metal affinity chromatography.
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Description : WHSC1 (Wolf-Hirschhorn syndrome candidate 1), also known as NSD2 (nuclear receptor binding SET domain protein 2), is a histone methyltransferase that adds methyl groups to histone H3 lysine 36 (H3K36). WHSC1/NSD2 is part of a family of SET domain-containing proteins that includes the closely related NSD1 and NSD3 proteins. WHSC1/NSD2 is involved in the regulation of gene expression, and has been shown to play a role in various cellular processes, including cell cycle progression, DNA damage response, and the maintenance of genomic stability. WHSC1/NSD2 is an important histone methyltransferase that plays a critical role in the regulation of gene expression and the maintenance of chromatin structure.
Source : E. coli
Species : Human
Protein length : 825-1208 aa
Form : 0.765 mg/ml of enzyme in 25mM Tris/HCl pH8, 100mM NaCl, 2.5mM TCEP, 2.5 mM imidazole, 50% Glycerol. Frozen solution.
Molecular Mass : 44.2 kDa
AA Sequence : 1 GHHAHVNVSW CFVCSKGGSL LCCESCPAAF HPDCLNIEMP DGSWFCNDCR 51 AGKKLHFQDI IWVKLGNYRW WPAEVCHPKN VPPNIQKMKH EIGEFPVFFF 101 GSKDYYWTHQ ARVFPYMEGD RGSRYQGVRG IGRVFKNALQ EAEARFREIK 151 LQREARETQE SERKPPPYKH IKVNKPYGKV QIYTADISEI PKCNCKPTDE 201 NPCGFDSECL NRMLMFECHP QVCPAGEFCQ NQCFTKRQYP ETKIIKTDGK 251 GWGLVAKRDI RKGEFVNEYV GELIDEEECM ARIKHAHEND ITHFYMLTID 301 KDRIIDAGPK GNYSRFMNHS CQPNCETLKW TVNGDTRVGL FAVCDIPAGT 351 ELTFNYNLDC LGNEKTVCRC GASNCSGFLG DRPKT
Applications : Drug Discovery & Development
Storage : 1 year at -70 centigrade.
Handling Advice : Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into prechilled micro-centrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70 centigrade.
Use/Stability : Stable for 1 year at -70 centigrade from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
Gene Name : NSD2 nuclear receptor binding SET domain protein 2 [ Homo sapiens (human) ]
Official Symbol : NSD2
Synonyms : NSD2; nuclear receptor binding SET domain protein 2; WHS; TRX5; KMT3F; KMT3G; MMSET; RAUST; WHSC1; REIIBP
Gene ID : 7468
mRNA Refseq : NM_007331.2
Protein Refseq : NP_015627.1
MIM : 602952
UniProt ID : O96028

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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