"NSD2" Related Products

Recombinant Human NSD2 protein, GST-tagged

Cat.No.: NSD2-258H
Product Overview: Recombinant Human NSD2(959-1365 aa)(Catalytic Domain) fused with GST tag at N-terminal was expressed in E. coli.
Description: NSD2/MMSET is a SET-domain containing histone methyltransferase, catalyzing the dimethylation of histone H3 at lysine 36. NSD2/MMSET, an oncogene that is overexpressed in several cancers, is thought to drive pathogenesis of t(4;14) positive multiple myeloma.
Source: E. coli
Species: Human
Tag : GST
Form: In 25 mM Tris pH 8.0, 150 mM NaCl, 1 mM DTT, 1 mM EDTA and 20% glycerol.
Molecular Mass: 61 kDa
Applications: NSD2 / MMSET Catalytic Domain, Recombinant Human is useful for histone H3 methylation experiments, enzyme kinetics and inhibitor screening. Use of 0.5 - 2 µg NSD2 per reaction with HeLa or recombinant nucleosomes as a substrate is recommended.
Storage: Stable for six months at -80 centigrade from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.
Concentration: 0.5 µg/µl
Gene Name: NSD2 nuclear receptor binding SET domain protein 2 [ Homo sapiens ]
Official Symbol: NSD2
Synonyms: WHS; TRX5; KMT3F; KMT3G; MMSET; WHSC1; REIIBP; IL5 promoter REII region-binding protein; Wolf-Hirschhorn syndrome candidate 1; multiple myeloma SET domain containing protein type III; nuclear SET domain-containing protein 2; probable histone-lysine N-methyltransferase NSD2; trithorax/ash1-related protein 5
Gene ID: 7468
mRNA Refseq: NM_001042424
Protein Refseq: NP_001035889
MIM: 602952
UniProt ID: O96028
Chromosome Location: 4p16.3
Pathway: Cell Cycle, organism-specific biosystem; Chromatin modifying enzymes, organism-specific biosystem; G2/M DNA damage checkpoint, organism-specific biosystem
Products Types

◆ Assay kits

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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