Recombinant Human NTRK2 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: NTRK2-4731H
• Product Overview: NTRK2 MS Standard C13 and N15-labeled recombinant protein (NP_001007098) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 53.1 kDa
• AA Sequence: MSSWIRWHGPAMARLWGFCWLVVGF WRAAFACPTSCKCSASRIWCSDPSP GIVAFPRLEPNSVDPENITEIFIAN QKRLEIINEDDVEAYVGLRNLTIVD SGLKFVAHKAFLKNSNLQHINFTRN KLTSLSRKHFRHLDLSELILVGNPF TCSCDIMWIKTLQEAKSSPDTQDLY CLNESSKNIPLANLQIPNCGLPSAN LAAPNLTVEEGKSITLSCSVAGDPV PNMYWDVGNLVSKHMNETSHTQGSL RITNISSDDSGKQISCVAENLVGED QDSVNLTVHFAPTITFLESPTSDHH WCIPFTVKGNPKPALQWFYNGAILN ESKYICTKIHVTNHTEYHGCLQLDN PTHMNNGDYTLIAKNEYGKDEKQIS AHFMGWPGIDDGANPNYPDVIYEDY GTAANDIGDTTNRSNEIPSTDVTDK TGREHLSVYAVVVIASVVGFCLLVM LFLLKLARHSKFGMKGFVLFHKIPL DGTRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: NTRK2 neurotrophic receptor tyrosine kinase 2 [ Homo sapiens (human) ]
• Official Symbol: NTRK2
• Synonyms: NTRK2; neurotrophic tyrosine kinase, receptor, type 2; BDNF/NT-3 growth factors receptor; TRKB; trkB tyrosine kinase; tyrosine kinase receptor B; tropomyosin-related kinase B; BDNF-tropomyosine receptor kinase B; trk-B; GP145-TrkB
• Gene ID: 4915
• mRNA Refseq: NM_001007097
• Protein Refseq: NP_001007098
• MIM: 600456
• UniProt ID: Q16620