Recombinant Human OPRM1 Protein, MYC/DDK-tagged
Cat.No. : | OPRM1-295H |
Product Overview : | Recombinant human OPRM1 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293. |
- Specification
- Gene Information
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Description : | Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A [UniProtKB/Swiss-Prot Function] |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol. |
Molecular Mass : | 44.6 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | opioid receptor mu 1 [ Homo sapiens ] |
Official Symbol : | OPRM1p |
Synonyms : | LMOR; M-OR-1; MOP; MOR; MOR1; OPRM |
Gene ID : | 4988 |
mRNA Refseq : | NM_000914.3 |
Protein Refseq : | NP_000905.3 |
MIM : | 600018 |
UniProt ID : | P35372 |
Products Types
◆ Recombinant Protein | ||
Oprm1-4596M | Recombinant Mouse Oprm1 Protein, Myc/DDK-tagged | +Inquiry |
OPRM1-511C | Recombinant Cynomolgus Monkey OPRM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
OPRM1-3858R | Recombinant Rat OPRM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
OPRM1-1583H | Recombinant Human OPRM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
OPRM1-2988R | Recombinant Rhesus Macaque OPRM1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Assay kits | ||
Kit-1460 | OPRM1 U2OS β-Arrestin GPCR Assay Kit | +Inquiry |
Kit-1462 | OPRM1 Total GPCR Internalization Assay Kit | +Inquiry |
Kit-1459 | OPRM1 CHO K1 β-Arrestin GPCR Assay Kit | +Inquiry |
Kit-1461 | OPRM1 U2OS β-Arrestin-1 GPCR Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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