Active Recombinant Human PARP1 Protein, GST-tagged

• Cat.No.: PARP1-010H
• Product Overview: Active recombinant human N-terminal GST-tagged full length PARP1 protein (2-1041) was expressed in insect cells.

Specification

• Description: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
• Source: Insect cell
• Species: Human
• Tag: GST
• Bio-activity: Ribosylation activity measured by chemiluminescent assay.
• Molecular Mass: 139 kDa
• Protein length: 2-1041
• Purity: ≥80% as determined by SDS-PAGE
• Stability: ≥ 2 years
• Storage: At -80 centigrade.
• Storage Buffer: 40 mM Tris, pH 8.0, with 110 mM NaCl, 2.2 mM KCl, 2 mM glutathione, 3 mM DTT and 20% glycerol

Gene Information

• Gene Name: PARP1 poly(ADP-ribose) polymerase 1 [ Homo sapiens (human) ]
• Official Symbol: PARP1
• Synonyms: PARP1; poly(ADP-ribose) polymerase 1; PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; poly [ADP-ribose] polymerase 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase NAD(+); ADP-ribosyltransferase diphtheria toxin-like 1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; poly (ADP-ribose) polymerase family, member 1; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; poly[ADP-ribose] synthase 1; protein poly-ADP-ribosyltransferase PARP1; EC 2.4.2.30
• Gene ID: 142
• mRNA Refseq: NM_001618
• Protein Refseq: NP_001609
• MIM: 173870
• UniProt ID: P09874