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Recombinant Human PARP1 Protein, MYC/DDK-tagged, C13 and N15-labeled

Cat.No. : PARP1-075H
Product Overview : PARP1 MS Standard C13 and N15-labeled recombinant protein (NP_001609) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 112.9 kDa
AA Sequence : MAESSDKLYRVEYAKSGRASCKKCS ESIPKDSLRMAIMVQSPMFDGKVPH WYHFSCFWKVGHSIRHPDVEVDGFS ELRWDDQQKVKKTAEAGGVTGKGQD GIGSKAEKTLGDFAAEYAKSNRSTC KGCMEKIEKGQVRLSKKMVDPEKPQ LGMIDRWYHPGCFVKNREELGFRPE YSASQLKGFSLLATEDKEALKKQLP GVKSEGKRKGDEVDGVDEVAKKKSK KEKDKDSKLEKALKAQNDLIWNIKD ELKKVCSTNDLKELLIFNKQQVPSG ESAILDRVADGMVFGALLPCEECSG QLVFKSDAYYCTGDVTAWTKCMVKT QTPNRKEWVTPKEFREISYLKKLKV KKQDRIFPPETSASVAATPPPSTAS APAAVNSSASADKPLSNMKILTLGK LSRNKDEVKAMIEKLGGKLTGTANK ASLCISTKKEVEKMNKKMEEVKEAN IRVVSEDFLQDVSASTKSLQELFLA HILSPWGAEVKAEPVEVVAPRGKSG AALSKKSKGQVKEEGINKSEKRMKL TLKGGAAVDPDSGLEHSAHVLEKGG KVFSATLGLVDIVKGTNSYYKLQLL EDDKENRYWIFRSWGRVGTVIGSNK LEQMPSKEDAIEHFMKLYEEKTGNA WHSKNFTKYPKKFYPLEIDYGQDEE AVKKLTVNPGTKSKLPKPVQDLIKM IFDVESMKKAMVEYEIDLQKMPLGK LSKRQIQAAYSILSEVQQAVSQGSS DSQILDLSNRFYTLIPHDFGMKKPP LLNNADSVQAKAEMLDNLLDIEVAY SLLRGGSDDSSKDPIDVNYEKLKTD IKVVDRDSEEAEIIRKYVKNTHATT HNAYDLEVIDIFKIEREGECQRYKP FKQLHNRRLLWHGSRTTNFAGILSQ GLRIAPPEAPVTGYMFGKGIYFADM VSKSANYCHTSQGDPIGLILLGEVA LGNMYELKHASHISKLPKGKHSVKG LGKTTPDPSANISLDGVDVPLGTGI SSGVNDTSLLYNEYIVYDIAQVNLK YLLKLKFNFKTSLWTRTRPLEQKLI SEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : PARP1 poly(ADP-ribose) polymerase 1 [ Homo sapiens (human) ]
Official Symbol : PARP1
Synonyms : PARP1; poly(ADP-ribose) polymerase 1; ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1; PARP; PARP-1; PPOL; poly [ADP-ribose] polymerase 1; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase NAD(+); ADP-ribosyltransferase diphtheria toxin-like 1; DNA ADP-ribosyltransferase PARP1; NAD(+) ADP-ribosyltransferase 1; poly (ADP-ribose) polymerase family, member 1; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; poly[ADP-ribose] synthase 1; protein poly-ADP-ribosyltransferase PARP1; EC 2.4.2.30
Gene ID : 142
mRNA Refseq : NM_001618
Protein Refseq : NP_001609
MIM : 173870
UniProt ID : P09874

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Does PARP1 protein cause cells to die in time? 12/30/2022

Yes, overactivation of the PARP1 protein can lead to apoptosis or necrosis of cells, which may be exploited in the treatment of certain diseases.

How is the PARP1 protein involved in DNA repair? 02/25/2022

The PARP1 protein can repair DNA damage by attaching ADP-ribose groups to damaged DNA strands and recruiting other repair proteins.

What are the other regulatory mechanisms of PARP1 protein in DNA damage repair? 01/07/2022

In addition to PARP1's involvement in direct DNA repair, it can also modulate the selection of repair pathways and initiate other DNA damage sensing mechanisms.

What is the potential of PARP1 protein in tumor immunotherapy? 09/29/2019

Some studies have proposed that the interaction of PARP1 protein with DNA damage in tumor immunotherapy may affect the efficacy of immunotherapy.

Is PARP1 protein involved in cell cycle regulation? 05/19/2019

Yes, the PARP1 protein is involved in the normal regulation of the cell cycle, especially G1/S and G2/M switching during DNA damage.

What are the effects of overactivation of PARP1 protein on cells? 01/07/2019

Overactivation of PARP1 depletes energy stores such as NAD+ and ATP and leads to apoptosis, or cell death.

Customer Reviews (3)

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Reviews
06/01/2020

    This range of applications of PARP1 is breathtaking, and it can play an important role in any field.

    12/02/2019

      This short half-life and high clearance of PARP1 make it have greater potential in the treatment of tumors, infections and other diseases, and it is expected to become a new generation of therapeutic drugs.

      03/18/2019

        The purity and bioactivity of PARP1 make it a valuable resource for scientific research.

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