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Recombinant Human PBX2 Protein, MYC/DDK-tagged

Cat.No. : PBX2-425H
Product Overview : Recombinant human PBX2 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
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Description : This gene encodes a ubiquitously expressed member of the TALE/PBX homeobox family. It was identified by its similarity to a homeobox gene which is involved in t(1;19) translocation in acute pre-B-cell leukemias. This protein is a transcriptional activator which binds to the TLX1 promoter. The gene is located within the major histocompatibility complex (MHC) on chromosome 6. [provided by RefSeq, Jul 2008]
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 45.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : PBX homeobox 2 [ Homo sapiens ]
Official Symbol : PBX2
Synonyms : G17; HOX12; PBX2MHC
Gene ID : 5089
mRNA Refseq : NM_002586.4
Protein Refseq : NP_002577.2
MIM : 176311
UniProt ID : P40425

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the mechanisms by which PBX2 modulates transcriptional networks in cells? 06/12/2022

PBX2 modulates transcriptional networks, coordinating the expression of multiple genes involved in development.

How do alterations in PBX2 expression or function affect congenital anomalies and developmental disorders? 04/04/2022

Changes in PBX2 expression or activity can lead to congenital anomalies and impact normal developmental processes.

What is the impact of PBX2 on oncogenesis and the progression of leukemia? 03/24/2022

PBX2 can influence oncogenesis, particularly in the development and progression of leukemias.

How does PBX2 influence the development of the central nervous system and neural differentiation? 04/28/2020

PBX2 is important for the development of the central nervous system, affecting neuronal differentiation and maturation.

How does PBX2 (Pre-B-Cell Leukemia Homeobox 2) regulate gene expression in developmental processes? 02/25/2020

PBX2 is involved in regulating gene expression, crucial for controlling developmental pathways and cell differentiation.

How does PBX2 contribute to the differentiation and function of hematopoietic cells? 10/29/2019

PBX2 contributes to the development of hematopoietic cells, impacting blood cell differentiation and function.

What role does PBX2 play in embryonic development, particularly in organogenesis? 10/07/2019

PBX2 plays a key role in embryonic development, influencing the formation of organs and tissues.

Customer Reviews (3)

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Reviews
09/13/2020

    Accurate mass spectrometry, a cornerstone of our proteomics work.

    11/12/2019

      Quick delivery, product as described.

      08/18/2019

        Dependable antibody validation, vital for our immunoprecipitation studies.

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