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Recombinant Human PLA2G12A Protein, MYC/DDK-tagged

Cat.No. : PLA2G12A-1881H
Product Overview : Recombinant human PLA2G12A protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293
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Description : Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008].
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 20.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : PLA2G12A phospholipase A2, group XIIA [ Homo sapiens ]
Official Symbol : PLA2G12A
Synonyms : GXII; PLA2G12; ROSSY
Gene ID : 81579
mRNA Refseq : NM_030821
Protein Refseq : NP_110448
MIM : 611652
UniProt ID : Q9BZM1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does PLA2G12A contribute to cell signaling pathways? 12/15/2022

PLA2G12A-generated lipid mediators can act as signaling molecules, influencing various cellular processes and pathways.

Can PLA2G12A be a therapeutic target for cancer treatment? 03/22/2022

Investigations are underway to explore the role of PLA2G12A in cancer progression, with the goal of identifying therapeutic strategies to target this protein.

How does PLA2G12A contribute to inflammatory responses? 01/17/2019

PLA2G12A is involved in the generation of lipid mediators, such as eicosanoids, which play a role in inflammation and immune responses.

Can the measurement of PLA2G12A levels be used as a diagnostic marker? 01/16/2019

Studies suggest that alterations in PLA2G12A expression or activity may serve as potential diagnostic markers for certain diseases, although more research is needed.

Are there any ongoing clinical trials targeting PLA2G12A? 03/23/2016

Information on current clinical trials targeting PLA2G12A can be obtained from databases like ClinicalTrials.gov, indicating the evolving interest in its therapeutic potential.

Customer Reviews (3)

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10/30/2017

    the manufacturer of the PLA2G12A protein plays a vital role in supporting my research endeavors.

    03/10/2017

      the manufacturer's commitment to ongoing innovation ensures that I have access to the most advanced and updated versions of the PLA2G12A protein.

      06/09/2016

        They proactively monitor scientific advancements and customer feedback to continually refine and improve the performance of the protein.

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