| Description : |
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
85 kDa |
| AA Sequence : |
MSFIDPYQHIIVEHQYSHKFTVVVL RATKVTKGAFGDMLDTPDPYVELFI STTPDSRKRTRHFNNDINPVWNETF EFILDPNQENVLEITLMDANYVMDE TLGTATFTVSSMKVGEKKEVPFIFN QVTEMVLEMSLEVCSCPDLRFSMAL CDQEKTFRQQRKEHIRESMKKLLGP KNSEGLHSARDVPVVAILGSGGGFR AMVGFSGVMKALYESGILDCATYVA GLSGSTWYMSTLYSHPDFPEKGPEE INEELMKNVSHNPLLLLTPQKVKRY VESLWKKKSSGQPVTFTDIFGMLIG ETLIHNRMNTTLSSLKEKVNTAQCP LPLFTCLHVKPDVSELMFADWVEFS PYEIGMAKYGTFMAPDLFGSKFFMG TVVKKYEENPLHFLMGVWGSAFSIL FNRVLGVSGSQSRGSTMEEELENIT TKHIVSNDSSDSDDESHEPKGTENE DAGSDYQSDNQASWIHRMIMALVSD SALFNTREGRAGKVHNFMLGLNLNT SYPLSPLSDFATQDSFDDDELDAAV ADPDEFERIYEPLDVKSKKIHVVDS GLTFNLPYPLILRPQRGVDLIISFD FSARPSDSSPPFKELLLAEKWAKMN KLPFPKIDPYVFDREGLKECYVFKP KNPDMEKDCPTIIHFVLANINFRKY KAPGVPRETEEEKEIADFDIFDDPE SPFSTFNFQYPNQAFKRLHDLMHFN TLNNIDVIKEAMVESIEYRRQNPSR CSVSLSNVEARRFFNKEFLSKPKAT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
