Recombinant Human PTPN2 Protein, MYC/DDK-tagged

• Cat.No.: PTPN2-3131H
• Product Overview: Recombinant Human PTPN2 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 40.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: PTPN2 protein tyrosine phosphatase, non-receptor type 2 [ Homo sapiens ]
• Official Symbol: PTPN2
• Synonyms: PTN2; PTPT; TC-PTP; TCELLPTP; TCPTP
• Gene ID: 5771
• mRNA Refseq: NM_001207013
• Protein Refseq: NP_001193942
• MIM: 176887
• UniProt ID: P17706