| Description : |
This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
71 kDa |
| AA Sequence : |
MDTMMLNVRNLFEQLVRRVEILSEG NEVQFIQLAKDFEDFRKKWQRTDHE LGKYKDLLMKAETERSALDVKLKHA RNQVDVEIKRRQRAEADCEKLERQI QLIREMLMCDTSGSIQLSEEQKSAL AFLNRGQPSSSNAGNKRLSTIDESG SILSDISFDKTDESLDWDSSLVKTF KLKKREKRRSTSRQFVDGPPGPVKK TRSIGSAVDQGNESIVAKTTVTVPN DGGPIEAVSTIETVPYWTRSRRKTG TLQPWNSDSTLNSRQLEPRTETDSV GTPQSNGGMRLHDFVSKTVIKPESC VPCGKRIKFGKLSLKCRDCRVVSHP ECRDRCPLPCIPTLIGTPVKIGEGM LADFVSQTSPMIPSIVVHCVNEIEQ RGLTETGLYRISGCDRTVKELKEKF LRVKTVPLLSKVDDIHAICSLLKDF LRNLKEPLLTFRLNRAFMEAAEITD EDNSIAAMYQAVGELPQANRDTLAF LMIHLQRVAQSPHTKMDVANLAKVF GPTIVAHAVPNPDPVTMLQDIKRQP KVVERLLSLPLEYWSQFMMVEQENI DPLHVIENSNAFSTPQTPDIKVSLL GPVTTPEHQLLKTPSSSSLSQRVRS TLTKNTPRFGSKSKSATNLGRQGNF FASPMLKTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
