| Description : |
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
160.7 kDa |
| AA Sequence : |
MSRPPPTGKMPGAPETAPGDGAGAS RQRKLEALIRDPRSPINVESLLDGL NSLVLDLDFPALRKNKNIDNFLNRY EKIVKKIRGLQMKAEDYDVVKVIGR GAFGEVQLVRHKASQKVYAMKLLSK FEMIKRSDSAFFWEERDIMAFANSP WVVQLFYAFQDDRYLYMVMEYMPGG DLVNLMSNYDVPEKWAKFYTAEVVL ALDAIHSMGLIHRDVKPDNMLLDKH GHLKLADFGTCMKMDETGMVHCDTA VGTPDYISPEVLKSQGGDGFYGREC DWWSVGVFLYEMLVGDTPFYADSLV GTYSKIMDHKNSLCFPEDAEISKHA KNLICAFLTDREVRLGRNGVEEIRQ HPFFKNDQWHWDNIRETAAPVVPEL SSDIDSSNFDDIEDDKGDVETFPIP KAFVGNQLPFIGFTYYRENLLLSDS PSCRETDSIQSRKNEESQEIQKKLY TLEEHLSNEMQAKEELEQKCKSVNT RLEKTAKELEEEITLRKSVESALRQ LEREKALLQHKNAEYQRKADHEADK KRNLENDVNSLKDQLEDLKKRNQNS QISTEKVNQLQRQLDETNALLRTES DTAARLRKTQAESSKQIQQLESNNR DLQDKNCLLETAKLKLEKEFINLQS ALESERRDRTHGSEIINDLQGRICG LEEDLKNGKILLAKVELEKRQLQER FTDLEKEKSNMEIDMTYQLKVIQQS LEQEEAEHKATKARLADKNKIYESI EEAKSEAMKEMEKKLLEERTLKQKV ENLLLEAEKRCSLLDCDLKQSQQKI NELLKQKDVLNEDVRNLTLKIEQET QKRCLTQNDLKMQTQQVNTLKMSEK QLKQENNHLMEMKMNLEKQNAELRK ERQDADGQMKELQDQLEAEQYFSTL YKTQVRELKEECEEKTKLGKELQQK KQELQDERDSLAAQLEITLTKADSE QLARSIAEEQYSDLEKEKIMKELEI KEMMARHKQELTEKDATIASLEETN RTLTSDVANLANEKEELNNKLKDVQ EQLSRLKDEEISAAAIKAQFEKQLL TERTLKTQAVNKLAEIMNRKEPVKR GNDTDVRRKEKENRKLHMELKSERE KLTQQMIKYQKELNEMQAQIAEESQ IRIELQMTLDSKDSDIEQLRSQLQA LHIGLDSSSIGSGPGDAEADDGFPE SRLEGWLSLPVRNNTKKFGWVKKYV IVSSKKILFYDSEQDKEQSNPYMVL DIDKLFHVRPVTQTDVYRADAKEIP RIFQILYANEGESKKEQEFPVEPVG EKSNYICHKGHEFIPTLYHFPTNCE ACMKPLWHMFKPPPALECRRCHIKC HKDHMDKKEEIIAPCKVYYDISTAK NLLLLANSTEEQQKWVSRLVKKIPK KPPAPDPFARSSPRTSMKIQQNQSI RRPSRQLAPNKPSTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
