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Recombinant Human RSPO1 Protein, His-tagged

Cat.No. : RSPO1-2024H
Product Overview : Recombinant Human R-Spondin 1 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Arg31-Ala263) of human R-Spondin 1 (Accession #NP_001033722.1) fused with a 6×His tag at the C-terminus.
Description : This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5 % mannitol.
Protein length : Arg31-Ala263
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : > 90% as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Gene Name : RSPO1 R-spondin 1 [ Homo sapiens ]
Official Symbol : RSPO1
Synonyms : RSPO1; R-spondin 1; R spondin homolog (Xenopus laevis); R-spondin-1; FLJ40906; RSPONDIN; R-spondin homolog; roof plate-specific spondin-1; RSPO; CRISTIN3; RP11-566C13.1;
Gene ID : 284654
mRNA Refseq : NM_001038633
Protein Refseq : NP_001033722
MIM : 609595
UniProt ID : Q2MKA7

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