| Description : |
This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
107.5 kDa |
| AA Sequence : |
MAAQRIRAANSNGLPRCKSEGTLID LSEGFSETSFNDIKVPSPSALLVDN PTPFGNAKEVIAIKDYCPTNFTTLK FSKGDHLYVLDTSGGEWWYAHNTTE MGYIPSSYVQPLNYRNSTLSDSGMI DNLPDSPDEVAKELELLGGWTDDKK VPGRMYSNNPFWNGVQTNPFLNGNV PVMPSLDELNPKSTVDLLLFDAGTS SFTESSSATTNSTGNIFDELPVTNG LHAEPPVRRDNPFFRSKRSYSLSEL SVLQAKSDAPTSSSFFTGLKSPAPE QFQSREDFRTAWLNHRKLARSCHDL DLLGQSPGWGQTQAVETNIVCKLDS SGGAVQLPDTSISIHVPEGHVAPGE TQQISMKALLDPPLELNSDRSCSIS PVLEVKLSNLEVKTSIILEMKVSAE IKNDLFSKSTVGLQCLRSDSKEGPY VSVPLNCSCGDTVQAQLHNLEPCMY VAVVAHGPSILYPSTVWDFINKKVT VGLYGPKHIHPSFKTVVTIFGHDCA PKTLLVSEVTRQAPNPAPVALQLWG KHQFVLSRPQDLKVCMFSNMTNYEV KASEQAKVVRGFQLKLGKVSRLIFP ITSQNPNELSDFTLRVQVKDDQEAI LTQFCVQTPQPPPKSAIKPSGQRRF LKKNEVGKIILSPFATTTKYPTFQD RPVSSLKFGKLLKTVVRQNKNHYLL EYKKGDGIALLSEERVRLRGQLWTK EWYIGYYQGRVGLVHTKNVLVVGRA RPSLCSGPELSTSVLLEQILRPCKF LTYIYASVRTLLMENISSWRSFADA LGYVNLPLTFFCRAELDSEPERVAS VLEKLKEDCNNTENKERKSFQKELV MALLKMDCQGLVVRLIQDFVLLTTA VEVAQRWRELAEKLAKVSKQQMDAY ESPHRDRNGVVDSEAMWKPAYDFLL TWSHQIGDSYRDVIQELHLGLDKMK NPITKRWKHLTGTLILVNSLDVLRA AAFSPADQDDFVITRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
