| Description : |
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
93.6 kDa |
| AA Sequence : |
MDESALLDLLECPVCLERLDASAKV LPCQHTFCKRCLLGIVGSRNELRCP ECRTLVGSGVEELPSNILLVRLLDG IKQRPWKPGPGGGSGTNCTNALRSQ SSTVANCSSKDLQSSQGGQQPRVQS WSPPVRGIPQLPCAKALYNYEGKEP GDLKFSKGDIIILRRQVDENWYHGE VNGIHGFFPTNFVQIIKPLPQPPPQ CKALYDFEVKDKEADKDCLPFAKDD VLTVIRRVDENWAEGMLADKIGIFP ISYVEFNSAAKQLIEWDKPPVPGVD AGECSSAAAQSSTAPKHSDTKKNTK KRHSFTSLTMANKSSQASQNRHSME ISPPVLISSSNPTAAARISELSGLS CSAPSQVHISTTGLIVTPPPSSPVT TGPSFTFPSDVPYQAALGTLNPPLP PPPLLAATVLASTPPGATAAAAAAG MGPRPMAGSTDQIAHLRPQTRPSVY VAIYPYTPRKEDELELRKGEMFLVF ERCQDGWFKGTSMHTSKIGVFPGNY VAPVTRAVTNASQAKVPMSTAGQTS RGVTMVSPSTAGGPAQKLQGNGVAG SPSVVPAAVVSAAHIQTSPQAKVLL HMTGQMTVNQARNAVRTVAAHNQER PTAAVTPIQVQNAAGLSPASVGLSH HSLASPQPAPLMPGSATHTAAISIS RASAPLACAAAAPLTSPSITSASLE AEPSGRIVTVLPGLPTSPDSASSAC GNSSATKPDKDSKKEKKGLLKLLSG ASTKRKPRVSPPASPTLEVELGSAE LPLQGAVGPELPPGGGHGRAGSCPV DGDGPVTTAVAGAALAQDAFHRKAS SLDSAVPIAPPPRQACSSLGPVLNE SRPVVCERHRVVVSYPPQSEAELEL KEGDIVFVHKKREDGWFKGTLQRNG KTGLFPGSFVENITRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
