Recombinant Human SIRPA Protein, Fc-tagged

• Cat.No.: SIRPA-520H
• Product Overview: Human SIRP alpha is expressed from mammalian with a Fc tag at the C-terminal. It contains Glu31-Arg370.

Specification

• Description: Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction."
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Protein length: Glu31-Arg370
• Endotoxin: Less than 0.5 EU per ug by the LAL method.
• Purity: > 95% as determined by Bis-Tris PAGE. > 95% as determined by HPLC.
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: SIRPA signal regulatory protein alpha [ Homo sapiens (human) ]
• Official Symbol: SIRPA
• Synonyms: BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1
• Gene ID: 140885
• mRNA Refseq: NM_001040022.1
• Protein Refseq: NP_001035111.1
• MIM: 602461
• UniProt ID: P78324