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Recombinant Human SIRPA Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : SIRPA-3222H
Product Overview : SIRPA MS Standard C13 and N15-labeled recombinant protein (NP_001035111) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 54.8 kDa
AA Sequence : MEPAGPAPGRLGPLLCLLLAASCAW SGVAGEEELQVIQPDKSVSVAAGES AILHCTVTSLIPVGPIQWFRGAGPA RELIYNQKEGHFPRVTTVSESTKRE NMDFSISISNITPADAGTYYCVKFR KGSPDTEFKSGAGTELSVRAKPSAP VVSGPAARATPQHTVSFTCESHGFS PRDITLKWFKNGNELSDFQTNVDPV GESVSYSIHSTAKVVLTREDVHSQV ICEVAHVTLQGDPLRGTANLSETIR VPPTLEVTQQPVRAENQVNVTCQVR KFYPQRLQLTWLENGNVSRTETAST VTENKDGTYNWMSWLLVNVSAHRDD VKLTCQVEHDGQPAVSKSHDLKVSA HPKEQGSNTAAENTGSNERNIYIVV GVVCTLLVALLMAALYLVRIRQKKA QGSTSSTRLHEPEKNAREITQDTND ITYADLNLPKGKKPAPQAAEPNNHT EYASIQTSPQPASEDTLTYADLDMV HLNRTPKQPAPKPEPSFSEYASVQV PRKTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : SIRPA signal-regulatory protein alpha [ Homo sapiens (human) ]
Official Symbol : SIRPA
Synonyms : SIRPA; signal-regulatory protein alpha; protein tyrosine phosphatase, non receptor type substrate 1, PTPNS1; tyrosine-protein phosphatase non-receptor type substrate 1; BIT; CD172a; MFR; MYD 1; P84; SHPS 1; SHPS1; SIRP; SIRP ALPHA 1; SIRPalpha; SIRPalpha2; myd-1 antigen; inhibitory receptor SHPS-1; macrophage fusion receptor; CD172 antigen-like family member A; tyrosine phosphatase SHP substrate 1; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; MYD-1; CD172A; PTPNS1;
Gene ID : 140885
mRNA Refseq : NM_001040022
Protein Refseq : NP_001035111
MIM : 602461
UniProt ID : P78324

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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09/30/2020

    I am thankful for the immense support provided by this protein reagent for my experimental work! 

    06/14/2020

      This protein substance is truly an indispensable tool in my laboratory!

      09/03/2019

        Its performance is stable and reliable, and the manufacturer's quality control ensures that every experiment runs smoothly.

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