| Description : |
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
83 kDa |
| AA Sequence : |
MSQWYELQQLDSKFLEQVHQLYDDS FPMEIRQYLAQWLEKQDWEHAANDV SFATIRFHDLLSQLDDQYSRFSLEN NFLLQHNIRKSKRNLQDNFQEDPIQ MSMIIYSCLKEERKILENAQRFNQA QSGNIQSTVMLDKQKELDSKVRNVK DKVMCIEHEIKSLEDLQDEYDFKCK TLQNREHETNGVAKSDQKQEQLLLK KMYLMLDNKRKEVVHKIIELLNVTE LTQNALINDELVEWKRRQQSACIGG PPNACLDQLQNWFTIVAESLQQVRQ QLKKLEELEQKYTYEHDPITKNKQV LWDRTFSLFQQLIQSSFVVERQPCM PTHPQRPLVLKTGVQFTVKLRLLVK LQELNYNLKVKVLFDKDVNERNTVK GFRKFNILGTHTKVMNMEESTNGSL AAEFRHLQLKEQKNAGTRTNEGPLI VTEELHSLSFETQLCQPGLVIDLET TSLPVVVISNVSQLPSGWASILWYN MLVAEPRNLSFFLTPPCARWAQLSE VLSWQFSSVTKRGLNVDQLNMLGEK LLGPNASPDGLIPWTRFCKENINDK NFPFWLWIESILELIKKHLLPLWND GCIMGFISKERERALLKDQQPGTFL LRFSESSREGAITFTWVERSQNGGE PDFHAVEPYTKKELSAVTFPDIIRN YKVMAAENIPENPLKYLYPNIDKDH AFGKYYSRPKEAPEPMELDGPKGTG YIKTELISVSEVTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
