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Recombinant Human STAT5A Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : STAT5A-4962H
Product Overview : STAT5A MS Standard C13 and N15-labeled recombinant protein (NP_003143) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 90.5 kDa
AA Sequence : MAGWIQAQQLQGDALRQMQVLYGQH FPIEVRHYLAQWIESQPWDAIDLDN PQDRAQATQLLEGLVQELQKKAEHQ VGEDGFLLKIKLGHYATQLQKTYDR CPLELVRCIRHILYNEQRLVREANN CSSPAGILVDAMSQKHLQINQTFEE LRLVTQDTENELKKLQQTQEYFIIQ YQESLRIQAQFAQLAQLSPQERLSR ETALQQKQVSLEAWLQREAQTLQQY RVELAEKHQKTLQLLRKQQTIILDD ELIQWKRRQQLAGNGGPPEGSLDVL QSWCEKLAEIIWQNRQQIRRAEHLC QQLPIPGPVEEMLAEVNATITDIIS ALVTSTFIIEKQPPQVLKTQTKFAA TVRLLVGGKLNVHMNPPQVKATIIS EQQAKSLLKNENTRNECSGEILNNC CVMEYHQATGTLSAHFRNMSLKRIK RADRRGAESVTEEKFTVLFESQFSV GSNELVFQVKTLSLPVVVIVHGSQD HNATATVLWDNAFAEPGRVPFAVPD KVLWPQLCEALNMKFKAEVQSNRGL TKENLVFLAQKLFNNSSSHLEDYSG LSVSWSQFNRENLPGWNYTFWQWFD GVMEVLKKHHKPHWNDGAILGFVNK QQAHDLLINKPDGTFLLRFSDSEIG GITIAWKFDSPERNLWNLKPFTTRD FSIRSLADRLGDLSYLIYVFPDRPK DEVFSKYYTPVLAKAVDGYVKPQIK QVVPEFVNASADAGGSSATYMDQAP SPAVCPQAPYNMYPQNPDHVLDQDG EFDLDETMDVARHVEELLRRPMDSL DSRLSPPAGLFTSARGSLSTRTRPL EQKLISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : STAT5A signal transducer and activator of transcription 5A [ Homo sapiens (human) ]
Official Symbol : STAT5A
Synonyms : STAT5A; signal transducer and activator of transcription 5A; STAT5; MGF;
Gene ID : 6776
mRNA Refseq : NM_003152
Protein Refseq : NP_003143
MIM : 601511
UniProt ID : P42229

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does STAT5A contribute to immune system regulation? 01/28/2022

STAT5A plays a crucial role in regulating immune responses by influencing the differentiation and function of immune cells such as T cells and natural killer cells.

Are there any ongoing clinical trials targeting STAT5A? 12/01/2020

Yes, several clinical trials are exploring the therapeutic potential of targeting STAT5A in different cancer types.

What challenges are associated with targeting STAT5A in clinical applications? 07/17/2019

One challenge is the need for specificity in targeting STAT5A to avoid adverse effects on normal cellular functions.

Can STAT5A be a prognostic marker in cancer patients? 01/05/2018

Elevated levels of activated STAT5A have been correlated with poor prognosis in certain cancers, suggesting its potential as a prognostic marker.

In which diseases are dysregulations of STAT5A associated? 12/25/2017

Dysregulations of STAT5A have been linked to leukemia, breast cancer, and prostate cancer, among other diseases.

Customer Reviews (3)

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Reviews
10/17/2022

    The manufacturer offers exceptional technical assistance, guiding researchers through various stages of their experiments.

    10/04/2016

      Its reliable bioactivity makes it an ideal choice for a diverse range of experimental applications.

      05/29/2016

        By providing comprehensive data and resources, the manufacturer enables researchers to design and implement their trials with confidence, ensuring the desired outcomes.

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