Recombinant Human STAT5A Protein, Myc/DDK-tagged, C13 and N15-labeled
Cat.No. : | STAT5A-4962H |
Product Overview : | STAT5A MS Standard C13 and N15-labeled recombinant protein (NP_003143) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 90.5 kDa |
AA Sequence : | MAGWIQAQQLQGDALRQMQVLYGQH FPIEVRHYLAQWIESQPWDAIDLDN PQDRAQATQLLEGLVQELQKKAEHQ VGEDGFLLKIKLGHYATQLQKTYDR CPLELVRCIRHILYNEQRLVREANN CSSPAGILVDAMSQKHLQINQTFEE LRLVTQDTENELKKLQQTQEYFIIQ YQESLRIQAQFAQLAQLSPQERLSR ETALQQKQVSLEAWLQREAQTLQQY RVELAEKHQKTLQLLRKQQTIILDD ELIQWKRRQQLAGNGGPPEGSLDVL QSWCEKLAEIIWQNRQQIRRAEHLC QQLPIPGPVEEMLAEVNATITDIIS ALVTSTFIIEKQPPQVLKTQTKFAA TVRLLVGGKLNVHMNPPQVKATIIS EQQAKSLLKNENTRNECSGEILNNC CVMEYHQATGTLSAHFRNMSLKRIK RADRRGAESVTEEKFTVLFESQFSV GSNELVFQVKTLSLPVVVIVHGSQD HNATATVLWDNAFAEPGRVPFAVPD KVLWPQLCEALNMKFKAEVQSNRGL TKENLVFLAQKLFNNSSSHLEDYSG LSVSWSQFNRENLPGWNYTFWQWFD GVMEVLKKHHKPHWNDGAILGFVNK QQAHDLLINKPDGTFLLRFSDSEIG GITIAWKFDSPERNLWNLKPFTTRD FSIRSLADRLGDLSYLIYVFPDRPK DEVFSKYYTPVLAKAVDGYVKPQIK QVVPEFVNASADAGGSSATYMDQAP SPAVCPQAPYNMYPQNPDHVLDQDG EFDLDETMDVARHVEELLRRPMDSL DSRLSPPAGLFTSARGSLSTRTRPL EQKLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name : | STAT5A signal transducer and activator of transcription 5A [ Homo sapiens (human) ] |
Official Symbol : | STAT5A |
Synonyms : | STAT5A; signal transducer and activator of transcription 5A; STAT5; MGF; |
Gene ID : | 6776 |
mRNA Refseq : | NM_003152 |
Protein Refseq : | NP_003143 |
MIM : | 601511 |
UniProt ID : | P42229 |
Products Types
◆ Recombinant Protein | ||
STAT5A-5438R | Recombinant Rat STAT5A Protein, His (Fc)-Avi-tagged | +Inquiry |
STAT5A-4334R | Recombinant Rhesus Macaque STAT5A Protein, His (Fc)-Avi-tagged | +Inquiry |
Stat5a-6172M | Recombinant Mouse Stat5a Protein, Myc/DDK-tagged | +Inquiry |
STAT5A-2117H | Recombinant Human STAT5A Protein, His (Fc)-Avi-tagged | +Inquiry |
STAT5A-9737Z | Recombinant Zebrafish STAT5A | +Inquiry |
◆ Lysates | ||
STAT5A-1416HCL | Recombinant Human STAT5A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionSTAT5A plays a crucial role in regulating immune responses by influencing the differentiation and function of immune cells such as T cells and natural killer cells.
Yes, several clinical trials are exploring the therapeutic potential of targeting STAT5A in different cancer types.
One challenge is the need for specificity in targeting STAT5A to avoid adverse effects on normal cellular functions.
Elevated levels of activated STAT5A have been correlated with poor prognosis in certain cancers, suggesting its potential as a prognostic marker.
Dysregulations of STAT5A have been linked to leukemia, breast cancer, and prostate cancer, among other diseases.
Customer Reviews (3)
Write a reviewThe manufacturer offers exceptional technical assistance, guiding researchers through various stages of their experiments.
Its reliable bioactivity makes it an ideal choice for a diverse range of experimental applications.
By providing comprehensive data and resources, the manufacturer enables researchers to design and implement their trials with confidence, ensuring the desired outcomes.
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