Recombinant Human STAT5B protein, His/MBP-tagged

• Cat.No.: STAT5B-343H
• Product Overview: Recombinant Human STAT5B(383-572 aa) fused with His/MBP tag was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
• Source: E. coli
• Species: Human
• Tag: His/MBP
• Form: Liquid in PBS
• Protein length: 383-572 aa
• Purity: SDS-PAGE >90%
• Applications: WB Positive Control
• Stability: Samples are stable for up to twelve months from date of receipt at -70ºC.
• Storage: Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: STAT5B signal transducer and activator of transcription 5B [ Homo sapiens ]
• Official Symbol: STAT5B
• Synonyms: STAT5B; signal transducer and activator of transcription 5B; transcription factor STAT5B; STAT5
• Gene ID: 6777
• mRNA Refseq: NM_012448
• Protein Refseq: NP_036580
• MIM: 604260
• UniProt ID: P51692