| Description : |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
94.1 kDa |
| AA Sequence : |
MSLWGLVSKMPPEKVQRLYVDFPQH LRHLLGDWLESQPWEFLVGSDAFCC NLASALLSDTVQHLQASVGEQGEGS TILQHISTLESIYQRDPLKLVATFR QILQGEKKAVMEQFRHLPMPFHWKQ EELKFKTGLRRLQHRVGEIHLLREA LQKGAEAGQVSLHSLIETPANGTGP SEALAMLLQETTGELEAAKALVLKR IQIWKRQQQLAGNGAPFEESLAPLQ ERCESLVDIYSQLQQEVGAAGGELE PKTRASLTGRLDEVLRTLVTSCFLV EKQPPQVLKTQTKFQAGVRFLLGLR FLGAPAKPPLVRADMVTEKQARELS VPQGPGAGAESTGEIINNTVPLENS IPGNCCSALFKNLLLKKIKRCERKG TESVTEEKCAVLFSASFTLGPGKLP IQLQALSLPLVVIVHGNQDNNAKAT ILWDNAFSEMDRVPFVVAERVPWEK MCETLNLKFMAEVGTNRGLLPEHFL FLAQKIFNDNSLSMEAFQHRSVSWS QFNKEILLGRGFTFWQWFDGVLDLT KRCLRSYWSDRLIIGFISKQYVTSL LLNEPDGTFLLRFSDSEIGGITIAH VIRGQDGSPQIENIQPFSAKDLSIR SLGDRIRDLAQLKNLYPKKPKDEAF RSHYKPEQMGKDGRGYVPATIKMTV ERDQPLPTPELQMPTMVPSYDLGMA PDSSMSMQLGPDMVPQVYPPHSHSI PPYQGLSPEESVNVLSAFQEPHLQM PPSLGQMSLPFDQPHPQGLLPCQPQ EHAVSSPDPLLCSDVTMVEDSCLSQ PVTAFPQGTWIGEDIFPPLLPPTEQ DLTKLLLEGQGESGGGSLGAQPLLQ PSHYGQSGISMSHMDLRANPSWTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
