Recombinant Human STK4 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: STK4-1862H
• Product Overview: STK4 MS Standard C13 and N15-labeled recombinant protein (NP_006273) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 55.6 kDa
• AA Sequence: METVQLRNPPRRQLKKLDEDSLTKQ PEEVFDVLEKLGEGSYGSVYKAIHK ETGQIVAIKQVPVESDLQEIIKEIS IMQQCDSPHVVKYYGSYFKNTDLWI VMEYCGAGSVSDIIRLRNKTLTEDE IATILQSTLKGLEYLHFMRKIHRDI KAGNILLNTEGHAKLADFGVAGQLT DTMAKRNTVIGTPFWMAPEVIQEIG YNCVADIWSLGITAIEMAEGKPPYA DIHPMRAIFMIPTNPPPTFRKPELW SDNFTDFVKQCLVKSPEQRATATQL LQHPFVRSAKGVSILRDLINEAMDV KLKRQESQQREVDQDDEENSEEDEM DSGTMVRAVGDEMGTVRVASTMTDG ANTMIEHDDTLPSQLGTMVINAEDE EEEGTMKRRDETMQPAKPSFLEYFE QKEKENQINSFGKSVPGPLKNSSDW KIPQDGDYEFLKSWTVEDLQKRLLA LDPMMEQEIEEIRQKYQSKRQPILD AIEAKKRRQQNFTRTRPLEQKLISE EDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: STK4 serine/threonine kinase 4 [ Homo sapiens (human) ]
• Official Symbol: STK4
• Synonyms: STK4; serine/threonine kinase 4; serine/threonine-protein kinase 4; kinase responsive to stress 2; KRS2; mammalian sterile 20 like 1; MST1; yeast Ste20 like; YSK3; MST-1; STE20-like kinase MST1; mammalian sterile 20-like 1; mammalian STE20-like protein kinase 1; serine/threonine-protein kinase Krs-2; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2)); DKFZp686A2068
• Gene ID: 6789
• mRNA Refseq: NM_006282
• Protein Refseq: NP_006273
• MIM: 604965
• UniProt ID: Q13043