Recombinant Human SUCLA2 Protein, MYC/DDK-tagged

• Cat.No.: SUCLA2-3042H
• Product Overview: Recombinant Human SUCLA2 fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Description: Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 44.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Notes: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: SUCLA2 succinate-CoA ligase ADP-forming beta subunit [ Homo sapiens ]
• Official Symbol: SUCLA2
• Synonyms: A-SCS; A-BETA; MTDPS5; SCS-betaA
• Gene ID: 8803
• mRNA Refseq: NM_003850
• Protein Refseq: NP_003841
• MIM: 603921
• UniProt ID: Q9P2R7