| Description : |
This gene encodes a tudor domain-containing protein and component of the chromatoid body, a type of ribonucleoprotein granule present in male germ cells. Studies in rodents have demonstrated a role for the encoded protein in spermiogenesis and the nonsense mediated decay (NMD) pathway. This protein is a major autoantigen in human patients with autoimmune polyendocrine syndrome type 1 (APS1). |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
236.3 kDa |
| AA Sequence : |
MCSTPGMPAPGASLALRVSFVDVHP DVIPVQLWGLVGERRGEYLRLSREI QEAAATRGQWALGSASASPGELCLV QVGLLWHRCRVVSRQAQESRVFLLD EGRTITAGAGSLAPGRREFFNLPSE VLGCVLAGLVPAGCGAGSGEPPQHW PADAVDFLSNLQGKEVHGCVLDVLL LHRLVLLEVPDVFQQMRELGLARRV PDSLFRSLLERYLTAATASVGSGVP VLSRVPLKQKQPGLDYFYPQLQLGV TEAVVITQVCHPHRIHCQLRSVSQE IHRLSESMAQVYRGSTGTGDENSTS ATWEEREESPDKPGSPCASCGLDGH WYRALLLETFRPQRCAQVLHVDYGR KELVSCSSLRYLLPEYFRMPVVTYP CALYGLWDGGRGWSRSQVGDLKTLI LGKAVNAKIEFYCSFEHVYYVSLYG EDGINLNRVFGVQSCCLADRVLQSQ ATEEEEPETSQSQSPAEEVDEEISL PALRSIRLKMNAFYDAQVEFVKNPS EFWIRLRKHNVTFSKLMRRMCGFYS SASKLDGVVLKPEPDDLCCVKWKEN GYYRAIVTKLDDKSVDVFLVDRGNS ENVDWYDVRMLLPQFRQLPILAVKC TLADIWPLGKTWSQEAVSFFKKTVL HKELVIHILDKQDHQYVIEILDESR TGEENISKVIAQAGYAKYQEFETKE NILVNAHSPGHVSNHFTTESNKIPF AKTGEGEQKAKRENKTTSVSKALSD TTVVTNGSTELVVQEKVKRASVYFP LMQNCLEIKPGSSSKGELEVGSTVE VRVSYVENPGYFWCQLTRNIQGLKT LMSDIQYYCKNTAAPHQRNTLACLA KRTVNRQWSRALISGIQSVEHVNVT FVDYGDREMVSVKNIYSISEEFLKV KAQAFRCSLYNLIQPVGQNPFVWDV KAIQAFNEFIDNAWQKNLELKCTIF ALASINEELFNIVDLLTPFQSACHF LVEKRLARPVKLQKPLESSVQLHSY FYSTHDMKIGSEELVYITHIDDPWT FYCQLARNANILEQLSCSITQLSKV LLNLKTSPLNPGTLCLAKYTDGNWY RGIVIEKEPKKVFFVDFGNIYVVTS DDLLPIPSDAYDVLLLPMQAVRCSL SDIPDHIPEEVVVWFQETILDKSLK ALVVAKDPDGTLIIELYGDNIQISA SINKKLGLLSYKDRIRKKESEVLCS TTETLEEKNENMKLPCTEYLSKSVG YKLPNKEILEESYKPQINSSYKELK LLQSLTKTNLVTQYQDSVGNKNSQV FPLTTEKKEEISAETPLKTARVEAT LSERKIGDSCDKDLPLKFCEFPQKT IMPGFKTTVYVSHINDLSDFYVQLI EDEAEISHLSERLNSVKTRPEYYVG PPLQRGDMICAVFPEDNLWYRAVIK EQQPNDLLSVQFIDYGNVSVVHTNK IGRLDLVNAILPGLCIHCSLQGFEV PDNKNSKKMMHYFSQRTSEAAIRCE FVKFQDRWEVILADEHGIIADDMIS RYALSEKSQVELSTQVIKSASSKSV NKSDIDTSVFLNWYNPEKKMIRAYA TVIDGPEYFWCQFADTEKLQCLEVE VQTAGEQVADRRNCIPCPYIGDPCI VRYREDGHYYRALITNICEDYLVSV RLVDFGNIEDCVDPKALWAIPSELL SVPMQAFPCCLSGFNISEGLCSQEG NDYFYEIITEDVLEITILEIRRDVC DIPLAIVDLKSKGKSINEKMEKYSK TGIKSALPYENIDSEIKQTLGSYNL DVGLKKLSNKAVQNKIYMEQQTDEL AEITEKDVNIIGTKPSNFRDPKTDN ICEGFENPCKDKIDTEELEGELECH LVDKAEFDDKYLITGFNTLLPHANE TKEILELNSLEVPLSPDDESKEFLE LESIELQNSLVVDEEKGELSPVPPN VPLSQECVTKGAMELFTLQLPLSCE AEKQPELELPTAQLPLDDKMDPLSL GVSQKAQESMCTEDMRKSSCVESFD DQRRMSLHLHGADCDPKTQNEMNIC EEEFVEYKNRDAISALMPLFSEEES SDGSKHNNGLPDHISAQLQNTYTLK AFTVGSKCVVWSSLRNTWSKCEILE TAEEGTRVLNLSNGMEEIVNPENVW NGIPKLDKSPPEKRGLEVMEITRTR PLEQKLISEEDLAANDILDYKDDDD KV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
