| Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]. |
| Source : |
CHO cell |
| Species : |
Human |
| Bio-activity : |
The ED50 is from 0.10 to 0.4 ng/ml, corresponding to a specific activity of 2.5-10 x 10^6 units/mg. |
| Molecular Mass : |
12.7 kDa |
| Endotoxin : |
Less than 0.01 ng per µg protein as determined by the LAL method. |
| Purity : |
> 98% as determined by Coomassie stained SDS-PAGE. |
| Concentration : |
Protein formulated and vialed at >50 µg/mL in specified buffer |
| Storage Buffer : |
25% Acetonitrile, 0.1% TFA (trifluoroacetic acid) |
