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Active Recombinant Human TLR3 protein, His-tagged

Cat.No. : TLR3-25H
Product Overview : Recombinant Human TLR3(Lys27-Ser711) fused with His tag at C-terminal was expressed in NS0.
  • Specification
  • Gene Information
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Source : Mammalian cells
Species : Human
Tag : His
Predicted N Terminal : Lys27
Form : Lyophilized from a 0.2 μm filtered solution in PBS.
Bio-activity : Measured by its ability to inhibit poly I:C induced IL-8 secretion by HEK293 human embryonic kidney cells transfected with TLR3. The ED50 for this effect is typically 5-10 µg/mL in the presence of 10 µg/mL of poly I:C.
Molecular Mass : Predicted Molecular Mass: 79.2 kDa;SDS-PAGE: 110-120 kDa, reducing conditions.
Protein length : Lys27-Ser711
Endotoxin : <0.1 EU per 1 mug of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : Reconstitute at 400 μg/mL in sterile PBS.
Shipping : The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Gene Name : TLR3 toll-like receptor 3 [ Homo sapiens ]
Official Symbol : TLR3
Synonyms : TLR3; toll-like receptor 3; CD283; IIAE2;
Gene ID : 7098
mRNA Refseq : NM_003265
Protein Refseq : NP_003256
MIM : 603029
UniProt ID : O15455
Chromosome Location : 4q35
Pathway : Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem; DAI mediated induction of type I IFNs, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, organism-specific biosystem;
Function : double-stranded RNA binding; double-stranded RNA binding; receptor activity; transmembrane signaling receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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