Active Recombinant Human TLR3 protein, His-tagged
Cat.No. : | TLR3-25H |
Product Overview : | Recombinant Human TLR3(Lys27-Ser711) fused with His tag at C-terminal was expressed in NS0. |
- Specification
- Gene Information
- Related Products
Source : | Mammalian cells |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Lys27 |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Bio-activity : | Measured by its ability to inhibit poly I:C induced IL-8 secretion by HEK293 human embryonic kidney cells transfected with TLR3. The ED50 for this effect is typically 5-10 µg/mL in the presence of 10 µg/mL of poly I:C. |
Molecular Mass : | Predicted Molecular Mass: 79.2 kDa;SDS-PAGE: 110-120 kDa, reducing conditions. |
Protein length : | Lys27-Ser711 |
Endotoxin : | <0.1 EU per 1 mug of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by silver stain |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 400 μg/mL in sterile PBS. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Gene Name : | TLR3 toll-like receptor 3 [ Homo sapiens ] |
Official Symbol : | TLR3 |
Synonyms : | TLR3; toll-like receptor 3; CD283; IIAE2; |
Gene ID : | 7098 |
mRNA Refseq : | NM_003265 |
Protein Refseq : | NP_003256 |
MIM : | 603029 |
UniProt ID : | O15455 |
Chromosome Location : | 4q35 |
Pathway : | Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem; DAI mediated induction of type I IFNs, organism-specific biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem; Herpes simplex infection, conserved biosystem; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, organism-specific biosystem; |
Function : | double-stranded RNA binding; double-stranded RNA binding; receptor activity; transmembrane signaling receptor activity; |
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◆ Lysates | ||
TLR3-642MCL | Recombinant Mouse TLR3 cell lysate | +Inquiry |
TLR3-2447MCL | Recombinant Mouse TLR3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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