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Active Recombinant Human TNFRSF1B protein

Cat.No. : TNFRSF1B-249H
Product Overview : Recombinant Human TNFRSF1B(Pro 24-Thr206) fused with an N-terminal Met was expressed in E. coli.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Source : E. coli
Species : Human
Form : 1 x PBS
Bio-activity : The ED50 is 0.15-0.5 µg/ml, corresponding to a specific activity of 2-6 x 103 units/mg, determined by a dose-dependent inhibition of 0.25 ng/ml TNF-a induced cytotoxicity in L929 mouse fibroblast cells in the presence of 4 µg/ml actinomycin D.
Molecular Mass : 20 kDa
Protein length : Pro 24-Thr206
Endotoxin : Less than 0.01 ng per µg protein as determined by the LAL method.
Purity : >95%, as determined by Coomassie stained SDS-PAGE
Concentration : Protein formulated and vialed at >50 ug/mL in specified buffer
Gene Name : TNFRSF1B tumor necrosis factor receptor superfamily, member 1B [ Homo sapiens ]
Official Symbol : TNFRSF1B
Synonyms : TNFRSF1B; tumor necrosis factor receptor superfamily, member 1B; TNFR2; tumor necrosis factor receptor superfamily member 1B; CD120b; p75; TNF R II; TNF R75; TNFBR; TNFR80; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; soluble TNFR1B variant 1; tumor necrosis factor receptor 2; tumor necrosis factor beta receptor; tumor necrosis factor receptor type II; tumor necrosis factor binding protein 2; TBPII; TNFR1B; TNF-R75; p75TNFR; TNF-R-II;
Gene ID : 7133
mRNA Refseq : NM_001066
Protein Refseq : NP_001057
MIM : 191191
UniProt ID : P20333

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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