Active Recombinant Human TNFRSF1B Protein
Cat.No. : | TNFRSF1B-01H |
Product Overview : | Recombinant human TNFRSF1B protein without tag was expressed in E. coli. The TNFR2 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. |
Source : | E. coil |
Species : | Human |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | The ED50 as determined by its ability to inhibit the TNF-a mediated cytotoxicity in the L-929 cells is less than 0.2 μg/mL, corresponding to a specific activity of > 5000 IU/mg in the presence of 0.25 ng/mL of rHuTNF-a. |
Molecular Mass : | 20 kDa |
Protein length : | 184 |
AA Sequence : | MPAQVAFTPYAPEPGSTCRLREYYD QTAQMCCSKCSPGQHAKVFCTKTSD TVCDSCEDSTYTQLWNWVPECLSCG SRCSSDQVETQACTREQNRICTCRP GWYCALSKQEGCRLCAPLRKCRPGF GVARPGTETSDVVCKPCAPGTFSNT TSSTDICRPHQICNVVAIPGNASMD AVCTSTSPT. |
Purity : | Greater than 97.0% as determined by SDS-PAGE. |
Stability : | Lyophilized TNFR2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 centigrade. Upon reconstitution TNFR2 should be stored at 4 centigrade between 2-7 days and for future use below -18 centigrade. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH7.4. |
Reconstitution : | It is recommended to reconstitute the lyophilized TNFR2 in sterile 18M-cm H2O not less than 100 μg/mL, which can then be further diluted to other aqueous solutions. |
Shipping : | Shipped at Room temp. |
Gene Name : | TNFRSF1B TNF receptor superfamily member 1B [ Homo sapiens (human) ] |
Official Symbol : | TNFRSF1B TNF receptor superfamily member 1B [ Homo sapiens (human) ] |
Synonyms : | TNFRSF1B; TNF receptor superfamily member 1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; tumor necrosis factor receptor 2; tumor necrosis factor receptor type II |
Gene ID : | 7133 |
mRNA Refseq : | NM_001066 |
Protein Refseq : | NP_001057 |
MIM : | 191191 |
UniProt ID : | P20333 |
Products Types
◆ Recombinant Protein | ||
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TNFRSF1B-5855R | Recombinant Rat TNFRSF1B Protein, His (Fc)-Avi-tagged | +Inquiry |
TNFRSF1B-4683R | Recombinant Rhesus Macaque TNFRSF1B Protein, His (Fc)-Avi-tagged | +Inquiry |
Tnfrsf1b-447M | Recombinant Mouse Tnfrsf1b Protein, His-tagged | +Inquiry |
◆ Lysates | ||
TNFRSF1B-1048CCL | Recombinant Cynomolgus TNFRSF1B cell lysate | +Inquiry |
TNFRSF1B-2192MCL | Recombinant Mouse TNFRSF1B cell lysate | +Inquiry |
TNFRSF1B-2632HCL | Recombinant Human TNFRSF1B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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